Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28121426 | 0.85 | CASP3 (0.46) | P2RX7CASP3SENP8SENP7SENP6 | |
| SCHEMBL3587106 | 0.84 | MAPT (0.46) | CASP3SENP8SENP7SENP6LMNA | |
| SCHEMBL20565261 | 0.83 | POLB (0.47) | P2RX7CASP3SENP8SENP7SENP6 | |
| SCHEMBL21522559 | 0.81 | PDCD1 (0.44) | P2RX7CASP3SENP8SENP7SENP6 | |
| SCHEMBL22028701 | 0.81 | KDM4E (0.41) | SMN1; SMN2LMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL14678422 | 0.81 | P2RX7 (0.47) | P2RX7SMN1; SMN2LMNAALDH1A1RAB9A | |
| SCHEMBL3110927 | 0.81 | SMN1; SMN2 (0.47) | P2RX7CASP3SENP8SENP7SENP6 | |
| SCHEMBL14267784 | 0.80 | KDM4E (0.40) | SMN1; SMN2LMNAALDH1A1POLBRAB9A | |
| SCHEMBL18481212 | 0.80 | MAPT (0.42) | CASP3SENP8SENP7SENP6SMN1; SMN2 | |
| SCHEMBL8998233 | 0.80 | KDM4E (0.43) | SMN1; SMN2LMNAALDH1A1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104513194-A | 2-chloro-3-aldehyde pyridine synthetic method | NANJING RED SUN CO LTD | 2015-04-15 | — | — | CN | claimed |
| US-12459942-B2 | Inhibiting (α-v)(β-6) integrin | MORPHIC THERAPEUTIC, INC. (US) | 2025-11-04 | — | — | US | disclosed |
| US-20240376095-A1 | INHIBITING (ALPHA-V)(BETA-6) INTEGRIN | SCHR¿DINGER, LLC | 2024-11-14 | — | — | US | disclosed |
| US-12139462-B2 | Pyridinone MK2 inhibitors and uses thereof | XINTHERA, INC. (US) | 2024-11-12 | — | — | US | disclosed |
| CN-118878533-A | Inhibition of αvβ6 integrin | 莫菲克医疗股份有限公司 | 2024-11-01 | — | — | CN | disclosed |
| US-20240300951-A1 | Pyrazolopyridinone Compounds | BEIGENE LTD. (KY) | 2024-09-12 | — | — | US | disclosed |
| US-20240270751-A1 | Pyrazolopyridinone Compounds | BEIGENE LTD. (KY) | 2024-08-15 | — | — | US | disclosed |
| CN-112805001-B | Inhibition of αvβ6 integrin | 莫菲克医疗股份有限公司 | 2024-07-23 | — | — | CN | disclosed |
| EP-4367099-A1 | PYRIDINONE MK2 INHIBITORS AND USES THEREOF | Xinthera, Inc. (US) | 2024-05-15 | — | — | EP | disclosed |
| CN-117836296-A | Pyrazolopyridone compounds | 百济神州有限公司 | 2024-04-05 | — | — | CN | disclosed |
| US-20080064691-A1 | Heterocyclic Amide Derivatives Which Possess Glycogen Phosphorylase Inhibitory Activity | ASTRAZENECA AB (SE) | 2008-03-13 | — | — | US | disclosed |
| WO-2007088345-A1 | THIENO-PYRIDINE DERIVATIVES AS MEK INHIBITORS | UCB PHARMA S.A. (BE) | 2007-08-09 | — | — | WO | disclosed |
| EP-0312243-B1 | Methyl 2-[2-(3-substituted phenoxy)pyridin-3-yl]-3-methoxypropenoatesand their use as fungicides | ZENECA LTD (GB) | 1996-08-07 | — | — | EP | disclosed |
| US-5198444-A | Methyl α-(2-substituted)pyrid-3-yl-β-methoxyacrylates, compositions containing them and their use as fungicides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-03-30 | — | — | US | disclosed |
| US-5158954-A | For agriculture | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-27 | — | — | US | disclosed |
| EP-0312221-B1 | CHEMICAL PROCESS FOR THE PREPARATION OF METHYL 2-(3-PHENOXYPYRID-2-YL)-3-PROPENOATES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-21 | — | — | EP | disclosed |
| US-5039810-A | Pyridyl propenoate compound | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-08-13 | — | — | US | disclosed |
| US-5008276-A | Plants | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-04-16 | — | — | US | disclosed |
| EP-0312243-A2 | Methyl 2-[2-(3-substituted phenoxy)pyridin-3-yl]-3-methoxypropenoatesand their use as fungicides | ZENECA LIMITED (GB) | 1989-04-19 | — | — | EP | disclosed |
| EP-0312221-A2 | Chemical process for the preparation of methyl 2-(3-phenoxypyrid-2-yl)-3-propenoates | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-04-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12139462-B2 | Pyridinone MK2 inhibitors and uses thereof | ENPP2, PLP2, PDXK | P2RX7 1226/4885CASP3 3188/4885SENP8 3851/4885 |
| US-12459942-B2 | Inhibiting (α-v)(β-6) integrin | ITGB6, ITGA6, ITGAV | P2RX7 2117/4885CASP3 1864/4885SENP8 3628/4885 |
| US-20240376095-A1 | INHIBITING (ALPHA-V)(BETA-6) INTEGRIN | ITGB6, ITGA6, ITGAV | P2RX7 2267/4885CASP3 1848/4885SENP8 3732/4885 |
| US-20240300951-A1 | Pyrazolopyridinone Compounds | NFATC1, CD4, PBK | P2RX7 337/4885CASP3 315/4885SENP8 2584/4885 |
| US-20240270751-A1 | Pyrazolopyridinone Compounds | NFATC1, CD4, PBK | P2RX7 337/4885CASP3 315/4885SENP8 2584/4885 |
| US-20080064691-A1 | Heterocyclic Amide Derivatives Which Possess Glycogen Phosphorylase Inhibitory Activity | PYGL, PYGM, GYS1 | P2RX7 2472/4885CASP3 2502/4885SENP8 3512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.