SCHEMBL4131368

SCHEMBL4131368

CO[Si](CCCn1c(=O)[nH]c(=O)n(CCC[Si](OC)(OC)OC)c1=O)(OC)OC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APEX1 P27695 1/20 0.42
PDE4A P27815 4/20 0.35
ADORA2A P29274 4/20 0.35
PDE4B Q07343 4/20 0.35
PDE4C Q08493 4/20 0.35
PDE4D Q08499 4/20 0.35
ADORA2B P29275 4/20 0.35
ADORA3 P0DMS8 2/20 0.35
MAPT P10636 1/20 0.32
ATM Q13315 1/20 0.32
ALDH1A1 P00352 2/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
PDE2A O00408 1/20 0.31
PDE3B Q13370 1/20 0.31
PDE3A Q14432 1/20 0.31
TLR7 Q9NYK1 1/20 0.31
KDM4E B2RXH2 1/20 0.31
BRD4 O60885 1/20 0.31
BRD2 P25440 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28880256 0.89 CYP3A4 (0.42) APEX1PDE4AADORA2APDE4BPDE4C
SCHEMBL155052 0.87 LMNA (0.33) PDE4AADORA2APDE4BPDE4CPDE4D
SCHEMBL557549 0.86 ADORA2B (0.35) PDE4AADORA2APDE4BPDE4CPDE4D
SCHEMBL12892325 0.83 PDE4A (0.33) PDE4AADORA2APDE4BPDE4CPDE4D
SCHEMBL4126092 0.83 APEX1 (0.40) APEX1PDE4AADORA2APDE4BPDE4C
SCHEMBL10015809 0.81 PDE4A (0.33) PDE4AADORA2APDE4BPDE4CPDE4D
SCHEMBL4117056 0.81 APEX1 (0.39) APEX1PDE4AADORA2APDE4BPDE4C
SCHEMBL3402639 0.81 LMNA (0.32) PDE4AADORA2APDE4BPDE4CPDE4D
SCHEMBL28636308 0.81 ALDH1A1 (0.32) PDE4AADORA2APDE4BPDE4CPDE4D
SCHEMBL9891728 0.80 RGS4 (0.42) PDE4AADORA2APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020130072-A1 COATING AGENT, COATING FILM, AND LAMINATE DIC株式会社 2020-06-25 WO disclosed
EP-2684690-B1 ADHESIVE-BONDED STRUCTURE COMPRISING BOTH ADHESIVE COMPOSITION AND WOOD MATERIAL KANEKA CORP (JP) 2018-02-21 EP disclosed
US-9023588-B2 Resist underlayer film forming composition containing silicon having nitrogen-containing ring NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2015-05-05 US disclosed
EP-2684690-A1 ADHESIVE-BONDED STRUCTURE COMPRISING BOTH ADHESIVE COMPOSITION AND WOOD MATERIAL Kaneka Corporation (JP) 2014-01-15 EP disclosed
EP-2538276-A1 COMPOSITION FOR FORMATION OF RESIST UNDERLAYER FILM CONTAINING SILICON HAVING NITROGEN-CONTAINING RING Nissan Chemical Industries, Ltd. (JP) 2012-12-26 EP disclosed
US-20120315765-A1 RESIST UNDERLAYER FILM FORMING COMPOSITION CONTAINING SILICON HAVING NITROGEN-CONTAINING RING NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2012-12-13 US disclosed
EP-1418021-B1 Polishing pad JSR CORP (JP) 2009-01-21 EP disclosed
EP-1348747-B1 Gas barrier coating composition and method for manufacturing same JSR CORP (JP) 2007-02-14 EP disclosed
US-6992123-B2 Polishing pad JSR CORPORATION (JP) 2006-01-31 US disclosed
US-20040118051-A1 Polishing pad JSR CORPORATION (JP) 2004-06-24 US disclosed
EP-1418021-A1 Polishing pad JSR Corporation (JP) 2004-05-12 EP disclosed
US-20030187113-A1 Gas barrier coating composition and method for manufacturing same JSR CORPORATION (JP) 2003-10-02 US disclosed
EP-1348747-A1 Gas barrier coating composition and method for manufacturing same JSR Corporation (JP) 2003-10-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120315765-A1 RESIST UNDERLAYER FILM FORMING COMPOSITION CONTAINING SILICON HAVING NITROGEN-CONTAINING RING SRSF1, SRSF7, SRRM2 APEX1 874/4885PDE4A 4755/4885ADORA2A 4617/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.