Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MME | P08473 | 7/20 | 0.45 |
| ▸ | ACE | P12821 | 5/20 | 0.45 |
| ▸ | ECE1 | P42892 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4635630 | 1.00 | PTGS1 (0.51) | PTGS1GSTK1ALDH1A1MAPTPTGS2 | |
| SCHEMBL4635618 | 1.00 | PTGS1 (0.51) | PTGS1GSTK1ALDH1A1MAPTPTGS2 | |
| SCHEMBL929620 | 0.90 | PTGS1 (0.43) | PTGS1GSTK1ALDH1A1MAPTPTGS2 | |
| SCHEMBL930399 | 0.86 | PTGS1 (0.41) | PTGS1GSTK1ALDH1A1MAPTPTGS2 | |
| SCHEMBL27639531 | 0.86 | ALDH1A1 (0.50) | PTGS1GSTK1ALDH1A1MAPTPTGS2 | |
| SCHEMBL930206 | 0.83 | PTGS1 (0.39) | PTGS1GSTK1ALDH1A1MAPTPTGS2 | |
| SCHEMBL930209 | 0.82 | PTGS1 (0.38) | PTGS1GSTK1ALDH1A1MAPTPTGS2 | |
| SCHEMBL19579377 | 0.82 | PTGS1 (0.58) | PTGS1GSTK1ALDH1A1MAPTPTGS2 | |
| SCHEMBL197221 | 0.80 | MAPT (0.50) | PTGS1GSTK1ALDH1A1MAPTPTGS2 | |
| SCHEMBL69148 | 0.80 | MAPT (0.50) | PTGS1GSTK1ALDH1A1MAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933642-B1 | SALT ENHANCING COMPOUNDS AND USE | HOFMANN THOMAS FRANK (DE) | 2011-12-21 | — | — | EP | claimed |
| US-20090155440-A1 | Salt Enhancing Compounds and Use | GIVAUDAN SA (CH) | 2009-06-18 | — | — | US | claimed |
| EP-3806661-B1 | USE OF ANTAGONISTS OF T2R54 | FIRMENICH INCORPORATED (US) | 2025-07-02 | — | — | EP | disclosed |
| EP-4566459-A2 | ANTAGONISTS OF T2R54 AND COMPOSITIONS AND USES THEREOF | Firmenich Incorporated (US) | 2025-06-11 | — | — | EP | disclosed |
| US-12295396-B2 | Antagonists of T2R54 and compositions and uses thereof | FIRMENICH INCORPORATED (US) | 2025-05-13 | — | — | US | disclosed |
| CN-119264123-A | Antagonists of T2R54, compositions thereof and uses thereof | 弗门尼舍公司 | 2025-01-07 | — | — | CN | disclosed |
| CN-113194742-B | Antagonists of T2R54, compositions thereof and uses thereof | 弗门尼舍公司 | 2024-09-27 | — | — | CN | disclosed |
| US-20240114942-A1 | Antagonists of T2R54 and Compositions and Uses Thereof | FIRMENICH INCORPORATED (US) | 2024-04-11 | — | — | US | disclosed |
| US-20240108040-A1 | HIGH INTENSITY SWEETENERS | FIRMENICH INCORPORATED (US) | 2024-04-04 | — | — | US | disclosed |
| US-11871772-B2 | Antagonists of T2R54 and compositions and uses thereof | FIRMENICH INCORPORATED (US) | 2024-01-16 | — | — | US | disclosed |
| US-11758933-B2 | High intensity sweeteners | FIRMENICH INCORPORATED (US) | 2023-09-19 | — | — | US | disclosed |
| US-20170119032-A1 | HIGH INTENSITY SWEETENERS | FIRMENICH INCORPORATED | 2017-05-04 | — | — | US | disclosed |
| WO-2017075257-A2 | HIGH INTENSITY SWEETENERS | SENOMYX, INC. (US) | 2017-05-04 | — | — | WO | disclosed |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2017-04-06 | — | — | US | disclosed |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | SENOMYX INC (US) | 2017-03-30 | — | — | US | disclosed |
| US-20160376263-A1 | BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF | SENOMYX INC (US) | 2016-12-29 | — | — | US | disclosed |
| EP-1933642-B1 | SALT ENHANCING COMPOUNDS AND USE | HOFMANN THOMAS FRANK (DE) | 2011-12-21 | — | — | EP | disclosed |
| US-20090155440-A1 | Salt Enhancing Compounds and Use | GIVAUDAN SA (CH) | 2009-06-18 | — | — | US | disclosed |
| EP-1933642-A1 | SALT ENHANCING COMPOUNDS AND USE | Thomas Frank Hofmann & Andreas Dunkel Inst. für Lebensmittelchemie (DE) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007042274-A1 | SALT ENHANCING COMPOUNDS AND USE | THOMAS FRANK HOFMANN & ANDREAS DUNKEL (DE) | 2007-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240108040-A1 | HIGH INTENSITY SWEETENERS | TAS2R40, TAS2R60, TAS1R1 | PTGS1 1786/4885GSTK1 3185/4885ALDH1A1 978/4885 |
| US-20170119032-A1 | HIGH INTENSITY SWEETENERS | TAS2R40, TAS2R60, TAS1R1 | PTGS1 1786/4885GSTK1 3185/4885ALDH1A1 978/4885 |
| US-11871772-B2 | Antagonists of T2R54 and compositions and uses thereof | TAS2R50, TAS2R30, TAS2R60 | PTGS1 2216/4885GSTK1 4513/4885ALDH1A1 3663/4885 |
| US-20160376263-A1 | BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF | TAS2R5, TAS1R1, TAS2R1 | PTGS1 3306/4885GSTK1 4404/4885ALDH1A1 1490/4885 |
| US-12295396-B2 | Antagonists of T2R54 and compositions and uses thereof | TAS2R50, TAS2R30, TAS2R60 | PTGS1 2216/4885GSTK1 4513/4885ALDH1A1 3663/4885 |
| US-20090155440-A1 | Salt Enhancing Compounds and Use | TAS1R1, TAS2R41, TAS2R40 | PTGS1 2559/4885GSTK1 4236/4885ALDH1A1 2141/4885 |
| US-20240114942-A1 | Antagonists of T2R54 and Compositions and Uses Thereof | TAS2R50, TAS2R30, TAS2R60 | PTGS1 2216/4885GSTK1 4513/4885ALDH1A1 3663/4885 |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | TRPA1, PDE6G, PDE6D | PTGS1 312/4885GSTK1 1061/4885ALDH1A1 1029/4885 |
| US-11758933-B2 | High intensity sweeteners | TAS2R40, TAS2R60, TAS1R1 | PTGS1 1786/4885GSTK1 3185/4885ALDH1A1 978/4885 |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | PTGS1 1378/4885GSTK1 1260/4885ALDH1A1 3880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.