Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.64 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.59 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1065004 | 0.90 | NAMPT (0.63) | NAMPTHSP90B1TRAP1HPGDNOTUM | |
| SCHEMBL29367465 | 0.89 | NAMPT (0.62) | NAMPTHSP90B1TRAP1HPGDHSP90AA1 | |
| SCHEMBL17618301 | 0.88 | TRAP1 (0.65) | NAMPTHSP90B1TRAP1HPGDNOTUM | |
| SCHEMBL30277860 | 0.87 | HPGD (0.73) | NAMPTHPGDNOTUMLMNAALDH1A1 | |
| SCHEMBL4279383 | 0.87 | HPGD (0.73) | NAMPTHPGDNOTUMLMNAALDH1A1 | |
| SCHEMBL1304055 | 0.86 | HSP90B1 (0.63) | NAMPTHSP90B1TRAP1HPGDNOTUM | |
| SCHEMBL3621450 | 0.84 | HPGD (0.52) | NAMPTHSP90B1TRAP1HPGDSIGMAR1 | |
| SCHEMBL31047689 | 0.84 | PKM (0.62) | NAMPTHSP90B1TRAP1HPGDNOTUM | |
| SCHEMBL11605873 | 0.83 | HPGD (0.59) | NAMPTHPGDSIGMAR1ALDH1A1ACHE | |
| SCHEMBL4155125 | 0.81 | NAMPT (0.59) | NAMPTHSP90B1TRAP1HPGDHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118496146-A | Preparation method of isoindoline diketone compound | 五邑大学 | 2024-08-16 | — | — | CN | disclosed |
| US-20180169117-A1 | PHARMACEUTICAL FORMULATION COMPRISING A SUBSTITUTED PHENYL - (1,3-DIHYDRO-ISOINDOL-2-YL) - METHANONE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-06-21 | — | — | US | disclosed |
| US-20090215742-A1 | AMIDE RESORCINOL COMPOUNDS | PFIZER, INC. | 2009-08-27 | — | — | US | disclosed |
| US-20090075978-A1 | SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING DRUGS | GRUNENTHAL GMBH (DE) | 2009-03-19 | — | — | US | disclosed |
| WO-2007079957-A1 | SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169117-A1 | PHARMACEUTICAL FORMULATION COMPRISING A SUBSTITUTED PHENYL - (1,3-DIHYDRO-ISOINDOL-2-YL) - METHANONE | SDHA, LDHA, ALDH5A1 | NAMPT 3162/4885HSP90B1 2642/4885TRAP1 1332/4885 |
| US-20090215742-A1 | AMIDE RESORCINOL COMPOUNDS | HSP90AB1, HSP90AA1, HSP90AB2P | NAMPT 843/4885HSP90B1 4/4885TRAP1 26/4885 |
| US-20090075978-A1 | SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING DRUGS | PCCA, PPARA, PTGES | NAMPT 1008/4885HSP90B1 835/4885TRAP1 2088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.