SCHEMBL4172895

SCHEMBL4172895

ClC1=C(Cl)C2C3C=CC(C3)C2C1

nearest known ligand 0.33

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.33
TDP1 Q9NUW8 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.32
LMNA P02545 1/20 0.32
HTT P42858 1/20 0.32
CYP3A4 P08684 1/20 0.32
MAPT P10636 1/20 0.32
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acrylic Acid SCHEMBL11135533 0.83 SMN1; SMN2 (0.33) ALDH1A1TDP1SMN1; SMN2LMNA
Methacrylic Acid SCHEMBL11139897 0.82 KMT2A (0.35) ALDH1A1TDP1SMN1; SMN2
SCHEMBL12952456 0.68 ALDH1A1 (0.45) ALDH1A1TDP1SMN1; SMN2LMNAHTT
SCHEMBL3422940 0.68 ALDH1A1 (0.35) ALDH1A1TDP1SMN1; SMN2LMNAHTT
SCHEMBL4110653 0.65 ALDH1A1 (0.33) ALDH1A1TDP1
SCHEMBL4100352 0.65 ALDH1A1 (0.33) ALDH1A1TDP1SMN1; SMN2LMNAHTT
SCHEMBL4099322 0.65 ALDH1A1 (0.35) ALDH1A1TDP1SMN1; SMN2LMNAHTT
SCHEMBL1730486 0.65 TRPM5 (0.35) ALDH1A1SMN1; SMN2LMNAHTTTSHR
SCHEMBL11881351 0.64 HSD17B10 (0.39) ALDH1A1TDP1
SCHEMBL11584661 0.63 ALDH1A1 (0.39) ALDH1A1TDP1SMN1; SMN2LMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1884519-B1 METAL HYDRIDE COMPLEX, METHOD OF HYDROGENATING RING-OPENING POLYMERIZATION POLYMER OF CYCLOOLEFIN, AND PROCESS FOR PRODUCING PRODUCT OF HYDROGENATION OF RING-OPENING POLYMERIZATION POLYMER OF CYCLOOLEFIN JSR CORP (JP) 2014-03-19 EP disclosed
US-20090176950-A1 METAL HYDRIDE COMPLEX, METHOD OF HYDROGENATING RING-OPENING POLYMERIZATION POLYMER OF CYCLOOLEFIN, AND PROCESS FOR PRODUCING PRODUCT OF HYDROGENATION OF RING-OPENING POLYMERIZATION POLYMER OF CYCLOOLEFIN JSR CORPORATION (JP) 2009-07-09 US disclosed
EP-1884519-A1 METAL HYDRIDE COMPLEX, METHOD OF HYDROGENATING RING-OPENING POLYMERIZATION POLYMER OF CYCLOOLEFIN, AND PROCESS FOR PRODUCING PRODUCT OF HYDROGENATION OF RING-OPENING POLYMERIZATION POLYMER OF CYCLOOLEFIN JSR Corporation (JP) 2008-02-06 EP disclosed
EP-0026295-A1 Process for preparing chlorinated cycloaliphatic (meth)acrylate compositions, a copolymer containing them, and 2,3-dichloro dicyclopentadiene (meth)acrylate THE DOW CHEMICAL COMPANY (US) 1981-04-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090176950-A1 METAL HYDRIDE COMPLEX, METHOD OF HYDROGENATING RING-OPENING POLYMERIZATION POLYMER OF CYCLOOLEFIN, AND PROCESS FOR PRODUCING PRODUCT OF HYDROGENATION OF RING-OPENING POLYMERIZATION POLYMER OF CYCLOOLEFIN HPD, HMOX2, HAO2 ALDH1A1 2201/4885TDP1 4564/4885SMN1; SMN2 4533/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.