Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4178985 | 0.86 | GBA1 (0.39) | GBA1PGK1HIF1ACYP1A2ALDH1A1 | |
| SCHEMBL4179058 | 0.83 | GBA1 (0.40) | GBA1PGK1HIF1ACYP1A2ALDH1A1 | |
| SCHEMBL4176452 | 0.83 | PGK1 (0.42) | GBA1PGK1HIF1AALDH1A1NAMPT | |
| SCHEMBL4185582 | 0.82 | GBA1 (0.39) | GBA1PGK1HIF1ACYP1A2ALDH1A1 | |
| SCHEMBL4184002 | 0.81 | GBA1 (0.43) | GBA1PGK1HIF1ACYP1A2NAMPT | |
| SCHEMBL13743048 | 0.78 | SMN1; SMN2 (0.48) | GBA1PGK1HIF1AALDH1A1NAMPT | |
| SCHEMBL4183367 | 0.78 | CYP2C19 (0.37) | GBA1PGK1HIF1ACYP1A2ALDH1A1 | |
| SCHEMBL4176021 | 0.77 | PDE10A (0.40) | GBA1PGK1HIF1AHTR2CHTR7 | |
| SCHEMBL4183055 | 0.77 | GBA1 (0.45) | GBA1PGK1HIF1ACYP1A2NAMPT | |
| SCHEMBL4183360 | 0.74 | ALDH1A1 (0.48) | PGK1CYP1A2ALDH1A1CYP2C19NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090198057-A1 | Certain Chemical Entities, Compositions, and Methods | CYTOKINETICS, INCORPORATED | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090198057-A1 | Certain Chemical Entities, Compositions, and Methods | MYLK, MYH2, MYH10 | GBA1 3801/4885PGK1 1620/4885HIF1A 3543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.