Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4177976 | 0.90 | KMT2A (0.31) | KMT2APDE4DRAD52KDM4EGAA | |
| SCHEMBL4189834 | 0.89 | MAPK1 (0.37) | KMT2APDE4DRAD52KDM4EHTT | |
| SCHEMBL4191730 | 0.88 | SLC10A2 (0.33) | SLC10A2AAK1KMT2APDE4DRAD52 | |
| SCHEMBL4185269 | 0.86 | KDM4E (0.34) | KMT2APDE4DRAD52KDM4EHTT | |
| SCHEMBL4182671 | 0.82 | KDR (0.35) | KMT2APDE4DHSP90AA1HSP90AB1KDM4E | |
| SCHEMBL4177982 | 0.80 | ACHE (0.40) | HSP90AA1HSP90AB1KDM4E | |
| SCHEMBL4183205 | 0.77 | KDM4E (0.33) | KMT2ARAD52KDM4EGAA | |
| SCHEMBL4178311 | 0.76 | PDE10A (0.35) | KMT2ARAD52KDM4EGAAHTT | |
| SCHEMBL4182845 | 0.73 | MAPT (0.34) | SLC10A2KMT2APDE4DRAD52KDM4E | |
| SCHEMBL4177971 | 0.73 | PRMT5 (0.39) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014730-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |