Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4185269 | 0.91 | KDM4E (0.34) | MAPK1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4177972 | 0.89 | SLC10A2 (0.33) | KDM4ERAD52KMT2AHTTPDE4D | |
| SCHEMBL4178311 | 0.87 | PDE10A (0.35) | MAPK1MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4177976 | 0.86 | KMT2A (0.31) | KDM4ERAD52KMT2APDPK1HTT | |
| SCHEMBL4182671 | 0.84 | KDR (0.35) | MAPTALDH1A1KDM4EKMT2AHPGD | |
| SCHEMBL4177982 | 0.83 | ACHE (0.40) | MAPTALDH1A1LMNAKDM4EHSD17B10 | |
| SCHEMBL4182845 | 0.78 | MAPT (0.34) | MAPK1MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL4191730 | 0.76 | SLC10A2 (0.33) | MAPTALDH1A1SMN1; SMN2RAD52KMT2A | |
| SCHEMBL4183205 | 0.73 | KDM4E (0.33) | MAPTKDM4ESMN1; SMN2HSD17B10RAD52 | |
| SCHEMBL4178062 | 0.72 | PDE4A (0.34) | ALDH1A1KDM4EHPGDTSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014730-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |