Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4182845 | 0.91 | MAPT (0.34) | PDE10AMEN1KMT2APOLBGAA | |
| SCHEMBL4191730 | 0.89 | SLC10A2 (0.33) | MEN1KMT2APOLBGAAHTT | |
| SCHEMBL4189834 | 0.87 | MAPK1 (0.37) | MEN1KMT2AHTTALDH1A1RAD52 | |
| SCHEMBL4183205 | 0.86 | KDM4E (0.33) | PDE10AMEN1KMT2APOLBGAA | |
| SCHEMBL4178062 | 0.84 | PDE4A (0.34) | POLBGAAHTTALDH1A1KDM4E | |
| SCHEMBL4187144 | 0.83 | ALDH1A1 (0.38) | KMT2AALDH1A1RAD52MAPTKDM4E | |
| SCHEMBL4185269 | 0.78 | KDM4E (0.34) | MEN1KMT2AHTTALDH1A1RAD52 | |
| SCHEMBL4177972 | 0.76 | SLC10A2 (0.33) | KMT2AGAAHTTRAD52KDM4E | |
| SCHEMBL7917644 | 0.74 | SREBF2 (0.41) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL4177976 | 0.73 | KMT2A (0.31) | PDE10AKMT2AGAAHTTRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014730-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |