Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | APAF1 | O14727 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775596 | 0.84 | PARP1 (0.39) | PARP1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL423378 | 0.79 | PARP1 (0.40) | PARP1TYRPTPRCADORA2AALDH1A1 | |
| SCHEMBL15775233 | 0.77 | MAPT (0.43) | PTPRCKMT2ARECQLALDH1A1MAPT | |
| SCHEMBL7264066 | 0.73 | MAOA (0.44) | SHMT2MEN1KMT2AKDM4EAPAF1 | |
| SCHEMBL15775665 | 0.72 | ALDH1A1 (0.40) | PARP1TYRPTPRCADORA2AKDM4E | |
| SCHEMBL15775366 | 0.72 | RAB9A (0.38) | PARP1TYRADORA2AMEN1KMT2A | |
| SCHEMBL15775307 | 0.70 | UGCG (0.41) | ADORA2AMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5440391 | 0.69 | ADORA2A (0.42) | PARP1PTPRCADORA2AMEN1USP2 | |
| SCHEMBL15775407 | 0.69 | CCNE2 (0.44) | PARP1KMT2AATMKDM4EALDH1A1 | |
| Bromide SCHEMBL15775497 | 0.69 | UGCG (0.40) | ADORA2AMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |