Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694481 | 0.88 | LOXL2 (0.48) | APPSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL2002218 | 0.86 | APP (0.47) | APPSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL18612365 | 0.85 | AURKB (0.48) | APPSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL8686061 | 0.85 | PPARA (0.45) | APPSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL8684173 | 0.85 | PPARA (0.45) | APPSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL13588690 | 0.85 | SMN1; SMN2 (0.50) | APPSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL18580309 | 0.85 | LTA4H (0.45) | APPSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL4246691 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AMAPTHTT | |
| SCHEMBL18580741 | 0.82 | APP (0.58) | APPSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL18554124 | 0.82 | SMN1; SMN2 (0.44) | APPSMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11083717-B2 | Compositions and methods for drug sensitization of parasites | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2021-08-10 | — | — | US | disclosed |
| US-11083717-B2 | Compositions and methods for drug sensitization of parasites | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2021-08-10 | — | — | US | disclosed |
| EP-3659597-A2 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | The Texas A&M University System (US) | 2020-06-03 | — | — | EP | disclosed |
| US-20200138796-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | THE TEXAS A&M UNIVERSITY SYSTEM | 2020-05-07 | — | — | US | disclosed |
| US-20200138796-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | THE TEXAS A&M UNIVERSITY SYSTEM | 2020-05-07 | — | — | US | disclosed |
| US-10543200-B2 | Compositions and methods for drug sensitization of parasites | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2020-01-28 | — | — | US | disclosed |
| US-10543200-B2 | Compositions and methods for drug sensitization of parasites | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2020-01-28 | — | — | US | disclosed |
| US-20190314381-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA | THE TEXAS A&M UNIVERSITY SYSTEM | 2019-10-17 | — | — | US | disclosed |
| US-20190314381-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA | THE TEXAS A&M UNIVERSITY SYSTEM | 2019-10-17 | — | — | US | disclosed |
| US-10300071-B2 | Compositions and methods for inhibition of mycobacteria | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2019-05-28 | — | — | US | disclosed |
| US-10300071-B2 | Compositions and methods for inhibition of mycobacteria | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2019-05-28 | — | — | US | disclosed |
| US-20180243275-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | THE TEXAS A&M UNIVERSITY SYSTEM | 2018-08-30 | — | — | US | disclosed |
| US-20170065601-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA | THE TEXAS A&M UNIVERSITY SYSTEM | 2017-03-09 | — | — | US | disclosed |
| US-20170065601-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA | THE TEXAS A&M UNIVERSITY SYSTEM | 2017-03-09 | — | — | US | disclosed |
| US-20170065601-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA | THE TEXAS A&M UNIVERSITY SYSTEM | 2017-03-09 | — | — | US | disclosed |
| US-20090203694-A1 | INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE | HURLEY TIMOTHY BRIAN | 2009-08-13 | — | — | US | disclosed |
| US-5077300-A | Parasiticides | CIBA-GEIGY CORPORATION (US) | 1991-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10300071-B2 | Compositions and methods for inhibition of mycobacteria | ME3, PGLS, GNPAT | APP 3877/4885SMN1; SMN2 4812/4885NPC1 1297/4885 |
| US-20180243275-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | ABCC1, SLC11A2, CYP3A43 | APP 4111/4885SMN1; SMN2 4303/4885NPC1 1440/4885 |
| US-20190314381-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA | ME3, PGLS, GNPAT | APP 3877/4885SMN1; SMN2 4812/4885NPC1 1297/4885 |
| US-20200138796-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | ABCC1, SLC11A2, ABCG2 | APP 4045/4885SMN1; SMN2 4367/4885NPC1 1324/4885 |
| US-20090203694-A1 | INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE | FDPS, UMPS, GGPS1 | APP 1248/4885SMN1; SMN2 4143/4885NPC1 163/4885 |
| US-10543200-B2 | Compositions and methods for drug sensitization of parasites | ABCC1, SLC11A2, ABCG2 | APP 4045/4885SMN1; SMN2 4367/4885NPC1 1324/4885 |
| US-11083717-B2 | Compositions and methods for drug sensitization of parasites | ABCC1, SLC11A2, ABCG2 | APP 4045/4885SMN1; SMN2 4367/4885NPC1 1324/4885 |
| US-20170065601-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA | ME3, PGLS, GNPAT | APP 3877/4885SMN1; SMN2 4812/4885NPC1 1297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.