Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.37 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | CDC25A | P30304 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020384 | 0.86 | SIGMAR1 (0.39) | SLC9A1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11389444 | 0.82 | MAPT (0.33) | SLC9A1MAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1649060 | 0.76 | TSHR (0.38) | MEN1KMT2AMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11709141 | 0.76 | LMNA (0.31) | MAPK1LMNA | |
| SCHEMBL9527213 | 0.76 | LMNA (0.31) | MAPK1LMNA | |
| SCHEMBL1989267 | 0.75 | MEN1 (0.42) | MEN1KMT2AMAPTTHRBMAPK1 | |
| SCHEMBL4908709 | 0.73 | P2RX4 (0.31) | CES1 | |
| SCHEMBL3523519 | 0.73 | LMNA (0.39) | SLC9A1MAPTALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL11276030 | 0.72 | MAOB (0.34) | MEN1KMT2A | |
| SCHEMBL11868744 | 0.72 | MAPT (0.38) | MEN1KMT2AMAPTTHRBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716279-B2 | Pharmaceutical compositions of clonazepam and method of use thereof | Jazz Pharmaceuticals, Inc. (US) | 2014-05-06 | — | — | US | disclosed |
| US-8609651-B2 | Pharmaceutical compositions of benzodiazepines and method of use thereof | Jazz Pharmaceuticals, Inc. (US) | 2013-12-17 | — | — | US | disclosed |
| EP-2056877-A2 | PHARMACEUTICAL COMPOSITIONS OF BENZODIAZEPINES AND METHODS OF USE THEREOF | Jazz Pharmaceuticals Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| US-20080076761-A1 | Pharmaceutical compositions of clonazepam and method of use thereof | JAZZ PHARMACEUTICALS (US) | 2008-03-27 | — | — | US | disclosed |
| US-20080070904-A1 | Pharmaceutical compositions of benzodiazepines and method of use thereof | JAZZ PHARMACEUTICALS (US) | 2008-03-20 | — | — | US | disclosed |
| WO-2008027395-A2 | PHARMACEUTICAL COMPOSITIONS OF BENZODIAZEPINES AND METHODS OF USE THEREOF | Jazz Pharmaceuticals, Inc. (US) | 2008-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076761-A1 | Pharmaceutical compositions of clonazepam and method of use thereof | GABBR1, GABRA5, GABBR2 | SLC9A1 2088/4885MEN1 1645/4885KMT2A 1482/4885 |
| US-20080070904-A1 | Pharmaceutical compositions of benzodiazepines and method of use thereof | GABRA5, GABBR1, GABRA6 | SLC9A1 1484/4885MEN1 1365/4885KMT2A 1914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.