SCHEMBL427634

SCHEMBL427634

O=S(=O)(Cl)c1ncccn1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.43
ALDH1A1 P00352 1/20 0.43
HSD17B10 Q99714 1/20 0.43
TRPV4 Q9HBA0 1/20 0.38
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
TDP2 O95551 1/20 0.33
NSD2 O96028 1/20 0.33
ABL1 P00519 1/20 0.33
PLCG1 P19174 1/20 0.33
CES1 P23141 1/20 0.33
PAX8 Q06710 1/20 0.33
RIN1 Q13671 1/20 0.33
THRB P10828 1/20 0.33
BLM P54132 1/20 0.33
KDM4E B2RXH2 1/20 0.33
PKM P14618 1/20 0.33
LMNA P02545 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5593062 0.75 TXNRD1 (0.37) TDP1ALDH1A1MEN1KMT2ATDP2
SCHEMBL8779774 0.74 ALDH1A1 (0.36) TDP1ALDH1A1HSD17B10CDC25BHSP90AA1
SCHEMBL330028 0.73 BLM (0.35) TDP1MEN1KMT2ATDP2NSD2
SCHEMBL29435677 0.71 TRPV4 (0.51) TDP1ALDH1A1HSD17B10TRPV4MEN1
SCHEMBL349118 0.71 TRPV4 (0.51) TDP1ALDH1A1HSD17B10TRPV4MEN1
SCHEMBL6968378 0.71 TDP2 (0.33) TDP1MEN1KMT2ATDP2NSD2
SCHEMBL4847957 0.71 TDP2 (0.33) TDP1MEN1KMT2ATDP2NSD2
SCHEMBL4062075 0.71 HSP90AA1 (0.38) TDP1ALDH1A1TRPV4MEN1KMT2A
SCHEMBL27303298 0.71 TRIM24 (0.34) TDP1MEN1KMT2ATDP2NSD2
SCHEMBL51141 0.71 CA1 (0.43) TDP1HSD17B10MEN1KMT2ATDP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 268 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119912662-A Epoxy resin curing agent for insulating castable and preparation method thereof 江苏三木化工股份有限公司 2025-05-02 CN claimed
CN-119912663-A Epoxy resin curing agent for corrosion prevention of stripping tower and preparation method thereof 江苏三木化工股份有限公司 2025-05-02 CN claimed
CN-110668952-B Preparation method of benzphetamine hydrochloride 安徽贝克制药股份有限公司 2023-06-27 CN claimed
CN-110642721-B Preparation method of selegiline hydrochloride 安徽贝克生物制药有限公司 2022-09-30 CN claimed
CN-110668952-A Preparation method of benzphetamine hydrochloride 安徽贝克联合制药有限公司 2020-01-10 CN claimed
CN-110642721-A Preparation method of selegiline hydrochloride 安徽贝克生物制药有限公司 2020-01-03 CN claimed
CN-107602566-B The synthetic method of florasulam intermediate JIANGSU AGRICULTURAL HORMONE ENGINEERING TECHNOLOGY RESEARCH CENTRE CO., LTD. (CN) 2019-11-01 CN claimed
CN-107602566-A The synthetic method of florasulam intermediate 江苏省农用激素工程技术研究中心有限公司 2018-01-19 CN claimed
CN-1039590-A Alkoxy-1, 2, 4-triazolo [1, 5-C ] pyrimidine-2-sulfonamides, processes for their preparation and intermediates DOW CHEMICAL CO (US) 1990-02-14 CN claimed
CN-119912662-A Epoxy resin curing agent for insulating castable and preparation method thereof 江苏三木化工股份有限公司 2025-05-02 CN disclosed
CN-119912663-A Epoxy resin curing agent for corrosion prevention of stripping tower and preparation method thereof 江苏三木化工股份有限公司 2025-05-02 CN disclosed
US-20250101003-A1 SPIROCYCLIC CAV2.3 ANTAGONISTS LARIO THERAPEUTICS LIMITED (GB) 2025-03-27 US disclosed
CN-113490668-B Compounds and compositions for the treatment of diseases associated with APJ receptor activity 安娜普尔纳生物股份有限公司 2025-02-25 CN disclosed
US-20240336590-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH APJ RECEPTOR ACTIVITY ANNAPURNA BIO, INC. 2024-10-10 US disclosed
CN-1071429-A The N-aryl-1,2 that replaces, the preparation method of 4-triazolo pyrimidine-2-sulphonamide DOWELANCO (US) 1993-04-28 CN disclosed
CN-1068824-A N-pyrazolyl-1, 2, 4-triazolo [1, 5-c ] pyrimidine-2-sulfonamides as herbicides DOWELANCO (US) 1993-02-10 CN disclosed
EP-0375076-A1 Heterocyclic herbicides SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1990-06-27 EP disclosed
CN-87103145-A Weedicide 1988-05-11 CN disclosed
US-4256888-A Preparation of 2-chloropyrimidines EASTMAN KODAK COMPANY (US) 1981-03-17 US disclosed
US-4128586-A Catalytic reduction of aromatic sulfonyl halides with hydrogen sulfide to yield aromatic thiols ALLIED CHEMICAL CORPORATION (US) 1978-12-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240336590-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH APJ RECEPTOR ACTIVITY APLNR, AGTR1, AGTR2 TDP1 3499/4885ALDH1A1 2778/4885HSD17B10 1493/4885
US-20250101003-A1 SPIROCYCLIC CAV2.3 ANTAGONISTS CACNA1A, CACNA1E, CACNA1S TDP1 3390/4885ALDH1A1 2756/4885HSD17B10 4042/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.