Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 2/20 | 0.32 |
| ▸ | FGF1 | P05230 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL30084855 | 1.00 | MEN1 (0.55) | MEN1KMT2ATHRBTDP1LMNA | |
| SCHEMBL9815017 | 0.97 | MEN1 (0.55) | MEN1KMT2ATHRBTDP1LMNA | |
| SCHEMBL4296859 | 0.88 | MEN1 (0.56) | MEN1KMT2ATHRBTDP1LMNA | |
| SCHEMBL9815014 | 0.86 | MEN1 (0.55) | MEN1KMT2ATHRBTDP1LMNA | |
| SCHEMBL4021394 | 0.86 | MEN1 (0.55) | MEN1KMT2ATDP1ALDH1A1KDM4E | |
| SCHEMBL28948590 | 0.86 | MEN1 (0.55) | MEN1KMT2ATHRBTDP1LMNA | |
| Potassium Ion SCHEMBL14695214 | 0.82 | MEN1 (0.43) | MEN1KMT2ATDP1LMNA | |
| SCHEMBL18031555 | 0.78 | MEN1 (0.66) | MEN1KMT2ATHRBTDP1LMNA | |
| SCHEMBL1369158 | 0.78 | DUSP5 (0.42) | MEN1KMT2ATHRBTDP1LMNA | |
| SCHEMBL101283 | 0.78 | KMT2A (0.57) | MEN1KMT2ATHRBTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11866588-B2 | Polymerizable near-IR dyes | PROFUSA, INC. (US) | 2024-01-09 | — | — | US | disclosed |
| US-20210040326-A1 | AZACYANINE DYES AND USE THEREOF | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2021-02-11 | — | — | US | disclosed |
| EP-3768780-A1 | AZACYANINE DYES AND USE THEREOF | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2021-01-27 | — | — | EP | disclosed |
| US-20200140690-A1 | POLYMERIZABLE NEAR-IR DYES | PROFUSA, INC. (US) | 2020-05-07 | — | — | US | disclosed |
| US-10633542-B2 | Azacyanine dyes and use thereof | Ecole polytechnique fédérale de Lausanne (EPFL) (CH) | 2020-04-28 | — | — | US | disclosed |
| US-20190292371-A1 | AZACYANINE DYES AND USE THEREOF | INTRACE MEDICAL SA (CH) | 2019-09-26 | — | — | US | disclosed |
| WO-2019180475-A1 | AZACYANINE DYES AND USE THEREOF | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2019-09-26 | — | — | WO | disclosed |
| US-20180079906-A1 | AZACYANINE DYES AND USE THEREOF | Ecole polytechnique fédérale de Lausanne (EPFL) (CH) | 2018-03-22 | — | — | US | disclosed |
| US-8071388-B2 | Compositions and methods for biodetection by nucleic acid-templated chemistry | ENSEMBLE THERAPEUTICS CORPORATION (US) | 2011-12-06 | — | — | US | disclosed |
| US-20090275142-A1 | COMPOSITIONS AND METHODS FOR BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY | ENSEMBLE THERAPEUTICS CORPORATION | 2009-11-05 | — | — | US | disclosed |
| EP-2066813-A2 | COMPOSITIONS AND METHODS FOR BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY | Ensemble Discovery Corporation (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008054600-A2 | COMPOSITIONS AND METHODS FOR BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY | ENSEMBLE DISCOVERY CORPORATION (US) | 2008-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275142-A1 | COMPOSITIONS AND METHODS FOR BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY | POLRMT, NT5C3B, RNGTT | MEN1 1957/4885KMT2A 3161/4885THRB 4465/4885 |
| US-20210040326-A1 | AZACYANINE DYES AND USE THEREOF | INMT, AZI2, MYADM | MEN1 541/4885KMT2A 574/4885THRB 2983/4885 |
| US-20190292371-A1 | AZACYANINE DYES AND USE THEREOF | INMT, AZI2, MYADM | MEN1 541/4885KMT2A 574/4885THRB 2983/4885 |
| US-10633542-B2 | Azacyanine dyes and use thereof | INMT, AZI2, MYADM | MEN1 541/4885KMT2A 574/4885THRB 2983/4885 |
| US-20180079906-A1 | AZACYANINE DYES AND USE THEREOF | INMT, AZI2, MYADM | MEN1 541/4885KMT2A 574/4885THRB 2983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.