Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30428749 | 0.85 | CCNB2 (0.52) | NPC1RAB9ATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6709201 | 0.85 | CCNB2 (0.52) | NPC1RAB9ATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11953003 | 0.83 | ALDH1A1 (0.51) | NPC1RAB9ATDP1ALDH1A1CYP3A4 | |
| SCHEMBL5628749 | 0.81 | ALDH1A1 (0.64) | NPC1RAB9ATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4984877 | 0.81 | TLR2 (0.53) | NPC1RAB9ATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL696160 | 0.80 | NPC1 (0.55) | NPC1RAB9ATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19511901 | 0.79 | ERN1 (0.60) | NPC1RAB9ATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3446415 | 0.79 | ALDH1A1 (0.54) | NPC1RAB9ATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2489060 | 0.78 | HTR1A (0.52) | NPC1RAB9ATDP1SMN1; SMN2HTR1A | |
| SCHEMBL9985970 | 0.77 | MRGPRX4 (0.50) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11724979-B2 | Process for the preparation of treprostinil | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. (HU) | 2023-08-15 | — | — | US | disclosed |
| US-20170313643-A1 | PROCESS FOR THE PREPARATION OF TREPROSTINIL | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. (HU) | 2017-11-02 | — | — | US | disclosed |
| WO-2016055819-A1 | PROCESS FOR THE PREPARATION OF TREPROSTINIL | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. (HU) | 2016-04-14 | — | — | WO | disclosed |
| US-9029607-B2 | Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation | ALPHORA RESEARCH INC. (CA) | 2015-05-12 | — | — | US | disclosed |
| US-9029607-B2 | Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation | ALPHORA RESEARCH INC. (CA) | 2015-05-12 | — | — | US | disclosed |
| US-9029607-B2 | Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation | ALPHORA RESEARCH INC. (CA) | 2015-05-12 | — | — | US | disclosed |
| US-20130331593-A1 | Synthesis Of Treprostinil And Intermediates Useful Therein | ALPHORA RESEARCH INC. (CA) | 2013-12-12 | — | — | US | disclosed |
| US-20130211145-A1 | Protected Aldehydes For Use As Intermediates In Chemical Syntheses, And Processes For Their Preparation | ALPHORA RESEARCH INC. (CA) | 2013-08-15 | — | — | US | disclosed |
| US-20130211145-A1 | Protected Aldehydes For Use As Intermediates In Chemical Syntheses, And Processes For Their Preparation | ALPHORA RESEARCH INC. (CA) | 2013-08-15 | — | — | US | disclosed |
| US-20130211145-A1 | Protected Aldehydes For Use As Intermediates In Chemical Syntheses, And Processes For Their Preparation | ALPHORA RESEARCH INC. (CA) | 2013-08-15 | — | — | US | disclosed |
| US-20120197041-A1 | TREPROSTINIL PRODUCTION | UNITED THERAPEUTICS CORPORATION | 2012-08-02 | — | — | US | disclosed |
| WO-2012009818-A1 | PROTECTED ALDEHYDES FOR USE AS INTERMEDIATES IN CHEMICAL SYNTHESES, AND PROCESSES FOR THEIR PREPARATION | ALPHORA RESEARCH INC. (CA) | 2012-01-26 | — | — | WO | disclosed |
| WO-2012009818-A1 | PROTECTED ALDEHYDES FOR USE AS INTERMEDIATES IN CHEMICAL SYNTHESES, AND PROCESSES FOR THEIR PREPARATION | ALPHORA RESEARCH INC. (CA) | 2012-01-26 | — | — | WO | disclosed |
| WO-2012009816-A1 | SYNTHESIS OF TREPROSTINIL AND INTERMEDIATES USEFUL THEREIN | ALPHORA RESEARCH INC. (CA) | 2012-01-26 | — | — | WO | disclosed |
| WO-2012009816-A1 | SYNTHESIS OF TREPROSTINIL AND INTERMEDIATES USEFUL THEREIN | ALPHORA RESEARCH INC. (CA) | 2012-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11724979-B2 | Process for the preparation of treprostinil | PTGIS, TFPI, TREH | NPC1 3135/4885RAB9A 3181/4885TDP1 1633/4885 |
| US-20120197041-A1 | TREPROSTINIL PRODUCTION | PTGIS, PTGIR, PTGES | NPC1 1940/4885RAB9A 2880/4885TDP1 1579/4885 |
| US-20170313643-A1 | PROCESS FOR THE PREPARATION OF TREPROSTINIL | PTGIS, CYP2C19, CYP2F1 | NPC1 1160/4885RAB9A 1874/4885TDP1 444/4885 |
| US-20130331593-A1 | Synthesis Of Treprostinil And Intermediates Useful Therein | MAOB, TERB1, TBXAS1 | NPC1 2929/4885RAB9A 1157/4885TDP1 1526/4885 |
| US-20130211145-A1 | Protected Aldehydes For Use As Intermediates In Chemical Syntheses, And Processes For Their Preparation | CYP1B1, MAOB, ALDH1B1 | NPC1 3493/4885RAB9A 1700/4885TDP1 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.