Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK2 | O95069 | 1/20 | 0.55 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.52 |
| ▸ | MASP2 | O00187 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 1/20 | 0.51 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.51 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6716884 | 0.85 | PDK1 (0.51) | KCNK2KCNK10KMT2AMEN1PDK1 | |
| SCHEMBL29118239 | 0.84 | ALDH1A1 (0.58) | KCNK2KCNK10KMT2AMEN1PKM | |
| SCHEMBL943096 | 0.84 | PDK1 (0.71) | PDK1PDK2PDK3PDK4TP53 | |
| SCHEMBL3591716 | 0.84 | PDK1 (0.50) | KMT2AMEN1PDK1PDK2PDK3 | |
| SCHEMBL8645992 | 0.84 | KDM4E (0.55) | KMT2AMEN1PKMPDK1PDK2 | |
| SCHEMBL9478517 | 0.84 | PDK1 (0.50) | KCNK2KCNK10KMT2AMEN1PDK1 | |
| SCHEMBL3994998 | 0.81 | CETP (0.59) | KMT2AMEN1PKMMASP2DHODH | |
| SCHEMBL27953738 | 0.81 | KMT2A (0.63) | KMT2APDK1PDK2PDK3PDK4 | |
| SCHEMBL8893663 | 0.80 | PTPN1 (0.64) | KMT2AMEN1PKMGRIK1NPC1 | |
| SCHEMBL9994315 | 0.80 | PDK2 (0.50) | KMT2APDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105837432-A | Novel preparation method of 3,5-dichlorobenzoyl chloride | 山东润博生物科技有限公司 | 2016-08-10 | — | — | CN | claimed |
| US-8809526-B2 | Synthesis of cyclopentaquinazolines | ONYX PHARMACEUTICALS, INC. (US) | 2014-08-19 | — | — | US | claimed |
| US-20130211082-A1 | Synthesis of Cyclopentaquinazolines | ONYX PHARMACEUTICALS, INC. (US) | 2013-08-15 | — | — | US | claimed |
| EP-2595966-A2 | SYNTHESIS OF CYCLOPENTAQUINAZOLINES | Onyx Pharmaceuticals, Inc. (US) | 2013-05-29 | — | — | EP | claimed |
| WO-2012011939-A2 | SYNTHESIS OF CYCLOPENTAQUINAZOLINES | ONYX PHARMACEUTICALS, INC. (US) | 2012-01-26 | — | — | WO | claimed |
| US-20090143411-A1 | Thiophens and Their Use as Anti-Tumor Agents | COMPASS PHARMACEUTICALS LLC (US) | 2009-06-04 | — | — | US | claimed |
| EP-1802634-A2 | THIOPHENS AND THEIR USE AS ANTI-TUMOR AGENTS | Compass Pharmaceuticals LLC (US) | 2007-07-04 | — | — | EP | claimed |
| WO-2006044826-A2 | THIOPHENS AND THEIR USE AS ANTI-TUMOR AGENTS | COMPASS PHARMACEUTICALS LLC (US) | 2006-04-27 | — | — | WO | claimed |
| EP-4626868-A1 | 3-PHENYLQUINAZOLINONES AS NOVEL ANTI-CANCER THERAPY | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2025-10-08 | — | — | EP | disclosed |
| WO-2024115673-A1 | 3-PHENYLQUINAZOLINONES AS NOVEL ANTI-CANCER THERAPY | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2024-06-06 | — | — | WO | disclosed |
| US-11508566-B2 | Use of anthranilic acid derivative as matrix for MALDI mass spectrometry | NATIONAL TAIWAN UNIVERSITY (TW) | 2022-11-22 | — | — | US | disclosed |
| US-20210066060-A1 | USE OF ANTHRANILIC ACID DERIVATIVE AS MATRIX FOR MALDI MASS SPECTROMETRY | NATIONAL TAIWAN UNIVERSITY (TW) | 2021-03-04 | — | — | US | disclosed |
| EP-2595966-B1 | SYNTHESIS OF CYCLOPENTAQUINAZOLINES | BTG INT LTD (GB) | 2020-10-28 | — | — | EP | disclosed |
| US-10188754-B2 | Compositions and methods for chemical exchange saturation transfer (CEST) based magnetic resonance imaging (MRI) | THE JOHNS HOPKINS UNIVERSITY (US) | 2019-01-29 | — | — | US | disclosed |
| US-5187173-A | Degenerative diseases such as emphysema, rheumatoid arthritis, pancreatitis, cyctic fibrosis and skin disorders | STERLING WINTHROP INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-5128339-A | Emphysema, rheumatoid arthritis, pancreatitis | STERLING WINTHROP INC. (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0483928-A1 | 2-Saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use | STERLING WINTHROP INC. (US) | 1992-05-06 | — | — | EP | disclosed |
| EP-0471756-A4 | SACCHARIN DERIVATIVES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND PREPARATION THEREOF | — | 1992-04-08 | — | — | EP | disclosed |
| EP-0471756-A1 | SACCHARIN DERIVATIVES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND PREPARATION THEREOF. | STERLING WINTHROP INC (US) | 1992-02-26 | — | — | EP | disclosed |
| WO-1990013549-A1 | SACCHARIN DERIVATIVES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND PREPARATION THEREOF | STERLING WINTHROP INC. (US) | 1990-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143411-A1 | Thiophens and Their Use as Anti-Tumor Agents | TP53, BRDT, VHL | KCNK2 4535/4885KCNK10 4519/4885KMT2A 3189/4885 |
| US-11508566-B2 | Use of anthranilic acid derivative as matrix for MALDI mass spectrometry | ACMSD, ANTXR2, HAAO | KCNK2 2202/4885KCNK10 2409/4885KMT2A 193/4885 |
| US-20130211082-A1 | Synthesis of Cyclopentaquinazolines | GLUL, QPCT, ASNS | KCNK2 3552/4885KCNK10 3069/4885KMT2A 1880/4885 |
| US-10188754-B2 | Compositions and methods for chemical exchange saturation transfer (CEST) based magnetic resonance imaging (MRI) | GART, SLC43A1, AADAT | KCNK2 3746/4885KCNK10 4230/4885KMT2A 904/4885 |
| US-20210066060-A1 | USE OF ANTHRANILIC ACID DERIVATIVE AS MATRIX FOR MALDI MASS SPECTROMETRY | ACMSD, ANTXR2, HAAO | KCNK2 2202/4885KCNK10 2409/4885KMT2A 193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.