Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methylprednisolone 21-Suleptanic Acid Ester. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 5/20 | 0.69 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.65 |
| ▸ | PGR | P06401 | 5/20 | 0.65 |
| ▸ | AR | P10275 | 2/20 | 0.65 |
| ▸ | F2 | P00734 | 1/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylprednisolone 21-Suleptanic Acid Ester SCHEMBL13524225 | 0.94 | NR3C1 (0.70) | NR3C1CYP3A4PGRARF2 | |
| SCHEMBL11201742 | 0.90 | NR3C1 (0.82) | NR3C1CYP3A4PGRARF2 | |
| SCHEMBL11329958 | 0.90 | NR3C1 (0.82) | NR3C1CYP3A4PGRARF2 | |
| SCHEMBL13653761 | 0.90 | NR3C1 (0.74) | NR3C1CYP3A4PGRARF2 | |
| Methylprednisolone 21-Suleptanic Acid Ester SCHEMBL6259094 | 0.89 | HIF1A (0.55) | NR3C1CYP3A4PGRARF2 | |
| SCHEMBL31249747 | 0.85 | NR3C1 (0.81) | NR3C1CYP3A4PGRARF2 | |
| SCHEMBL10910221 | 0.85 | NR3C1 (0.85) | NR3C1CYP3A4PGRARF2 | |
| SCHEMBL29358979 | 0.85 | NR3C1 (0.71) | NR3C1CYP3A4PGRARF2 | |
| Hydrochloric Acid SCHEMBL31249697 | 0.85 | NR3C1 (0.80) | NR3C1CYP3A4PGRARF2 | |
| SCHEMBL11207103 | 0.84 | NR3C1 (0.82) | NR3C1CYP3A4PGRARF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4122 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12550643-B2 | Oxidants and strained-ring precursors | APPLIED MATERIALS, INC. (US) | 2026-02-10 | — | — | US | claimed |
| CN-119973454-A | PCBA welding quality prediction method and system based on time series data | 中国电子科技集团公司第三十八研究所 | 2025-05-13 | — | — | CN | claimed |
| CN-119943235-A | Steam curing-free low-carbon ultra-high-performance concrete mixing proportion design method | 福建省高速公路科技创新研究院有限公司 | 2025-05-06 | — | — | CN | claimed |
| CN-119813292-A | MPSO-based wind-solar-hydrogen storage micro-grid system capacity optimization configuration method | 中国矿业大学 | 2025-04-11 | — | — | CN | claimed |
| CN-119670996-A | Wind farm emergency operation and maintenance method, device and medium | 电子科技大学中山学院 | 2025-03-21 | — | — | CN | claimed |
| CN-119646653-A | Ship key component health state prediction method based on MPSO-RBF neural network | 中国舰船研究设计中心 | 2025-03-18 | — | — | CN | claimed |
| CN-115733888-B | Method for supporting self-adaptive unloading of multiple Internet of things applications in edge environment | 福州大学 | 2025-02-14 | — | — | CN | claimed |
| CN-119291683-A | Sub-aperture dividing and rapid focusing imaging method and device of terahertz frequency band | 中国人民解放军国防科技大学 | 2025-01-10 | — | — | CN | claimed |
| CN-114649821-B | Multi-objective hierarchical optimization scheduling method for new energy micro-grid containing electric automobile | 三峡大学 | 2024-12-20 | — | — | CN | claimed |
| CN-114677167-B | Logistics enterprise user loss prediction method | 南京邮电大学 | 2024-12-06 | — | — | CN | claimed |
| WO-2001015744-A9 | SYSTEMIC INFLAMMATORY MARKERS AS DIAGNOSTIC TOOLS IN THE PREVENTION OF ATHEROSCLEROTIC DISEASES | BRIGHAM & WOMENS HOSPITAL (US) | 2002-09-26 | — | — | WO | claimed |
| EP-1212101-A1 | SYSTEMIC INFLAMMATORY MARKERS AS DIAGNOSTIC TOOLS IN THE PREVENTION OF ATHEROSCLEROTIC DISEASES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2002-06-12 | — | — | EP | claimed |
| JP-2001525058-A | — | — | 2001-12-04 | — | — | JP | claimed |
| WO-2001015744-A1 | SYSTEMIC INFLAMMATORY MARKERS AS DIAGNOSTIC TOOLS IN THE PREVENTION OF ATHEROSCLEROTIC DISEASES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2001-03-08 | — | — | WO | claimed |
| EP-1003501-A4 | MEANS OF ASCERTAINING AN INDIVIDUAL'S RISK PROFILE FOR ATHEROSCLEROTIC DISEASE | BRIGHAM & WOMENS HOSPITAL (US) | 2001-01-17 | — | — | EP | claimed |
| EP-1003501-A1 | MEANS OF ASCERTAINING AN INDIVIDUAL'S RISK PROFILE FOR ATHEROSCLEROTIC DISEASE | BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2000-05-31 | — | — | EP | claimed |
| WO-1998043630-A1 | MEANS OF ASCERTAINING AN INDIVIDUAL'S RISK PROFILE FOR ATHEROSCLEROTIC DISEASE | BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 1998-10-08 | — | — | WO | claimed |
| EP-0374166-B1 | AMINE SALTS OF ALKANE-1,N-DICARBOXYLIC ACID MONO-(2-SULFATO-ETHYL)AMIDES | THE UPJOHN COMPANY (US) | 1993-01-07 | — | — | EP | claimed |
| EP-0374166-A1 | AMINE SALTS OF ALKANE-1,n-DICARBOXYLIC ACID MONO-(2-SULFATO-ETHYL)AMIDES. | UPJOHN CO (US) | 1990-06-27 | — | — | EP | claimed |
| WO-1989000558-A1 | AMINE SALTS OF ALKANE-1,n-DICARBOXYLIC ACID MONO-(2-SULFATO-ETHYL)AMIDES | THE UPJOHN COMPANY (US) | 1989-01-26 | — | — | WO | claimed |