SCHEMBL435279

SCHEMBL435279

Fc1ccc[c]c1-c1ccc(Cl)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
CASP3 P42574 2/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
NFE2L2 Q16236 1/20 0.35
AR P10275 1/20 0.35
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
TP53 P04637 2/20 0.32
TSHR P16473 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL150096 0.83 MAOB (0.32) NPC1RAB9ANFE2L2ARMAOB
SCHEMBL28360893 0.82 L3MBTL1 (0.35) CYP1A2NPC1RAB9ACASP3SENP8
SCHEMBL3607306 0.81 ALDH1A1 (0.35) NPC1RAB9AL3MBTL1NFE2L2AR
SCHEMBL18952590 0.80 APEX1 (0.43) CYP1A2NPC1RAB9ACASP3SENP8
SCHEMBL1491042 0.80 ALDH1A1 (0.38) NPC1RAB9AMEN1KMT2ATSHR
SCHEMBL16058080 0.79 ALOX5 (0.42) NPC1RAB9ATP53TSHRSMN1; SMN2
SCHEMBL435757 0.79 CYP1A2 (0.41) CYP1A2NPC1RAB9ACASP3SENP8
SCHEMBL4653269 0.78 CYP1A2 (0.39) CYP1A2NPC1RAB9ACASP3SENP8
SCHEMBL9265689 0.76 CYP1A2 (0.38) CYP1A2ALOX5LMNACYP2A6AHR
SCHEMBL16720201 0.76 ALOX5 (0.45) CYP1A2NPC1RAB9AL3MBTL1AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2595984-A1 MICROBICIDES Syngenta Participations AG (CH) 2013-05-29 EP disclosed
EP-2595985-A1 ISOXAZOLE, ISOTHIAZOLE, FURANE AND THIOPHENE COMPOUNDS AS MICROBICIDES Syngenta Participations AG (CH) 2013-05-29 EP disclosed
WO-2012010567-A1 ISOXAZOLE, ISOTHIAZOLE, FURANE AND THIOPHENE COMPOUNDS AS MICROBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2012-01-26 WO disclosed
WO-2012010568-A1 MICROBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2012-01-26 WO disclosed
US-4084063-A PROSTAGLANDINS; ANTIULCER AGENTS, ANTICOAGULANTS, OXYTOCICS, DECONGESTANTS THE UPJOHN COMPANY (US) 1978-04-11 US disclosed