Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 2/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4342153 | 0.85 | DGAT1 (0.42) | KDM4EGLADGAT1AKR1C3AKR1C2 | |
| SCHEMBL17797003 | 0.84 | KEAP1 (0.48) | KDM4EDCLRE1BMEN1KMT2ATTR | |
| SCHEMBL14873563 | 0.83 | AKR1C3 (0.53) | KDM4EGLADGAT1AKR1C3AKR1C2 | |
| SCHEMBL19767751 | 0.82 | AKR1C3 (0.51) | KDM4EGLAAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL629723 | 0.80 | AKR1C3 (0.64) | KDM4EGLAAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL593271 | 0.79 | ACLY (0.54) | KDM4EGLAAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL17796931 | 0.77 | ALDH1A1 (0.48) | AKR1C2AKR1C1MYCALDH1A1ACMSD | |
| SCHEMBL31279164 | 0.76 | AKR1C3 (0.43) | KDM4EGLADGAT1AKR1C3AKR1C2 | |
| SCHEMBL18223995 | 0.76 | KDM1A (0.54) | KDM4EAKR1C3AKR1C2AKR1C1ACLY | |
| SCHEMBL156346 | 0.74 | DGAT1 (0.68) | KDM4EGLADGAT1MYCNR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544400-B2 | Bimesogenic compounds and flexoelectric devices | MERCK PATENT GMBH (DE) | 2009-06-09 | — | — | US | disclosed |
| US-20080142758-A1 | Bimesogenic Compounds And Flexoelectric Devices | MERCK PATENT GMBH (DE) | 2008-06-19 | — | — | US | disclosed |
| EP-1828345-B1 | BIMESOGENIC COMPOUNDS AND FLEXOELECTRIC DEVICES | MERCK PATENT GMBH (DE) | 2008-05-14 | — | — | EP | disclosed |
| EP-1828345-A1 | BIMESOGENIC COMPOUNDS AND FLEXOELECTRIC DEVICES | Merck Patent GmbH (DE) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006066688-A1 | BIMESOGENIC COMPOUNDS AND FLEXOELECTRIC DEVICES | MERCK PATENT GMBH (DE) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080142758-A1 | Bimesogenic Compounds And Flexoelectric Devices | MLX, FOXM1, SFXN1 | KDM4E 4627/4885GLA 2636/4885DGAT1 4596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.