Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2532092 | 0.98 | GALR3 (0.50) | SMN1; SMN2NFKB1MAPTBLMKDM4E | |
| Hydrochloric Acid SCHEMBL2013485 | 0.98 | SMN1; SMN2 (0.49) | SMN1; SMN2NFKB1MAPTBLMKDM4E | |
| SCHEMBL435873 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2NFKB1MAPTBLMKDM4E | |
| SCHEMBL10618828 | 0.82 | KDM4E (0.57) | SMN1; SMN2NFKB1MAPTBLMKDM4E | |
| SCHEMBL112337 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2NFKB1MAPTBLMKDM4E | |
| SCHEMBL112338 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2NFKB1MAPTBLMKDM4E | |
| SCHEMBL8119128 | 0.78 | BLM (0.45) | SMN1; SMN2NFKB1MAPTBLMKDM4E | |
| SCHEMBL4258837 | 0.78 | CHRM1 (0.43) | SMN1; SMN2NFKB1MAPTBLMCHRM1 | |
| SCHEMBL113052 | 0.78 | SMN1; SMN2 (0.52) | SMN1; SMN2NFKB1MAPTBLMKDM4E | |
| SCHEMBL113051 | 0.78 | SMN1; SMN2 (0.52) | SMN1; SMN2NFKB1MAPTBLMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170189429-A1 | Treating Arrhythmia with Mitochondrial-Targeted Antioxidants | RHODE ISLAND HOSPITAL | 2017-07-06 | — | — | US | claimed |
| EP-3166600-A1 | TREATING ARRHYTHMIA WITH MITOCHONDRIAL-TARGETED ANTIOXIDANTS | Rhode Island Hospital (US) | 2017-05-17 | — | — | EP | claimed |
| WO-2016007921-A1 | TREATING ARRHYTHMIA WITH MITOCHONDRIAL-TARGETED ANTIOXIDANTS | RHODEL ISLAND HOSPITAL (US) | 2016-01-14 | — | — | WO | claimed |
| US-20070099845-A1 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | ROCHESTER, UNIVERSITY OF | 2007-05-03 | — | — | US | claimed |
| EP-1691818-A4 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | UNIV ROCHESTER (US) | 2007-01-24 | — | — | EP | claimed |
| EP-1691818-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | University of Rochester (US) | 2006-08-23 | — | — | EP | claimed |
| WO-2005051978-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | UNIVERSITY OF ROCHESTER (US) | 2005-06-09 | — | — | WO | claimed |
| US-10994082-B2 | Inhaler counter | ASTRAZENECA AB (SE) | 2021-05-04 | — | — | US | disclosed |
| US-20190175849-A1 | INHALER COUNTER | BANG & OLUFSEN MEDICOM A/S (DK) | 2019-06-13 | — | — | US | disclosed |
| US-20180339119-A1 | INHALER | BANG & OLUFSEN MEDICOM A/S (DK) | 2018-11-29 | — | — | US | disclosed |
| EP-2755707-B1 | INHALER | ASTRAZENECA AB (SE) | 2018-11-14 | — | — | EP | disclosed |
| EP-3345644-A1 | INHALER | Astrazeneca AB (SE) | 2018-07-11 | — | — | EP | disclosed |
| EP-2755708-B1 | INHALER | ASTRAZENECA AB (SE) | 2018-05-09 | — | — | EP | disclosed |
| WO-2007062343-A2 | MITOCHONDRIA-TARGETED ANTIOXIDANT PRODRUGS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2007-05-31 | — | — | WO | disclosed |
| US-20070099845-A1 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | ROCHESTER, UNIVERSITY OF | 2007-05-03 | — | — | US | disclosed |
| EP-1691818-A4 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | UNIV ROCHESTER (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-1691818-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | University of Rochester (US) | 2006-08-23 | — | — | EP | disclosed |
| US-20060160748-A1 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | ROCHESTER, UNIVERSITY OF | 2006-07-20 | — | — | US | disclosed |
| US-20060122267-A1 | Compositions and methods for attenuating mitochondria-mediated cell injury | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-06-08 | — | — | US | disclosed |
| WO-2005051978-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | UNIVERSITY OF ROCHESTER (US) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170189429-A1 | Treating Arrhythmia with Mitochondrial-Targeted Antioxidants | COQ8A, SQOR, COQ8B | SMN1; SMN2 2388/4885NFKB1 1920/4885MAPT 3872/4885 |
| US-20070099845-A1 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | TXN2, GLS, PDF | SMN1; SMN2 1355/4885NFKB1 687/4885MAPT 3404/4885 |
| US-20060160748-A1 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | TXN2, TXNRD2, HSPA9 | SMN1; SMN2 1123/4885NFKB1 778/4885MAPT 3187/4885 |
| US-20060122267-A1 | Compositions and methods for attenuating mitochondria-mediated cell injury | SHMT2, TXN2, TXNRD2 | SMN1; SMN2 960/4885NFKB1 1395/4885MAPT 2218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.