SCHEMBL4359338

SCHEMBL4359338

NC(=O)Nc1ccccc1-c1ccccc1Cl

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.56
KDM4E B2RXH2 5/20 0.49
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
ALDH1A1 P00352 2/20 0.47
HTT P42858 1/20 0.47
GAA P10253 1/20 0.47
HPGD P15428 1/20 0.46
CYP2C19 P33261 1/20 0.46
LMNA P02545 1/20 0.45
MAPT P10636 1/20 0.44
PKM P14618 1/20 0.44
CHRM3 P20309 1/20 0.43
DHODH Q02127 1/20 0.42
NPC1 O15118 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15259585 0.88 KDM4E (0.57) CYP1A2KDM4EMEN1KMT2AALDH1A1
SCHEMBL5113547 0.85 MAPT (0.49) CYP1A2KDM4EMEN1KMT2AALDH1A1
SCHEMBL2175829 0.84 CYP1A2 (0.75) CYP1A2KDM4EMEN1KMT2AALDH1A1
SCHEMBL29537172 0.84 CYP1A2 (0.75) CYP1A2KDM4EMEN1KMT2AALDH1A1
SCHEMBL9537879 0.83 L3MBTL1 (0.52) CYP1A2KDM4EMEN1KMT2AALDH1A1
SCHEMBL27782792 0.81 CYP1A2 (0.56) CYP1A2KDM4EMEN1KMT2AALDH1A1
SCHEMBL29840068 0.78 GAA (0.67) CYP1A2KDM4EMEN1KMT2AALDH1A1
Cyclopropane SCHEMBL29022116 0.78 CYP1A2 (0.68) CYP1A2KDM4EMEN1KMT2AALDH1A1
SCHEMBL2068768 0.78 LMNA (0.68) CYP1A2KDM4EMEN1KMT2AALDH1A1
SCHEMBL3928666 0.78 GAA (0.67) CYP1A2KDM4EMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210219546-A1 METHODS OF TREATING CROP PLANTS ALTER DOMUS US LLC 2021-07-22 US disclosed
EP-3294052-A1 METHODS OF TREATING CROP PLANTS Agrofresh, Inc. (US) 2018-03-21 EP disclosed
WO-2016182995-A1 METHODS OF TREATING CROP PLANTS AGROFRESH INC (US) 2016-11-17 WO disclosed
US-20150282479-A1 METHODS OF TREATING CROP PLANTS AGROFRESH, INC. 2015-10-08 US disclosed
US-9055741-B2 Contacting crop plants with compositions ROHM AND HAAS COMPANY (US) 2015-06-16 US disclosed
EP-1856976-B1 Contacting crop plants with compositions ROHM & HAAS (US) 2014-09-03 EP disclosed
EP-2070419-A1 A liquid composition for treating plants Rohm and Haas Company (US) 2009-06-17 EP disclosed
EP-1856976-A2 Contacting crop plants with compositions Rohm and Haas Company (US) 2007-11-21 EP disclosed
US-20070265166-A1 Contacting crop plants with compositions ALTER DOMUS US LLC 2007-11-15 US disclosed
US-20070117720-A1 Compositions with cyclopropenes AGROFRESH, INC. 2007-05-24 US disclosed
EP-1787513-A2 Compositions with cyclopropenes Rohm and Haas Company (US) 2007-05-23 EP disclosed
US-20060160704-A1 Plant growth regulation BASEL RICHARD M 2006-07-20 US disclosed
EP-1680960-A1 Plant growth regulation Rohm and Haas Company (US) 2006-07-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070265166-A1 Contacting crop plants with compositions PIN1, MYB, CROCC CYP1A2 834/4885KDM4E 1920/4885MEN1 4248/4885
US-20060160704-A1 Plant growth regulation MYB, SLTM, YAP1 CYP1A2 798/4885KDM4E 2520/4885MEN1 3961/4885
US-20150282479-A1 METHODS OF TREATING CROP PLANTS CYCS, NOP2, CNPY3 CYP1A2 1237/4885KDM4E 3297/4885MEN1 4372/4885
US-20070117720-A1 Compositions with cyclopropenes MYB, OSBP, FAR1 CYP1A2 873/4885KDM4E 4041/4885MEN1 3749/4885
US-20210219546-A1 METHODS OF TREATING CROP PLANTS CYCS, NOP2, CNPY3 CYP1A2 1237/4885KDM4E 3297/4885MEN1 4372/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.