SCHEMBL436207

SCHEMBL436207

CC(C)(C)OC(=O)c1cc(N)ccc1C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.51
MAPT P10636 4/20 0.49
KDM4E B2RXH2 4/20 0.49
TDP1 Q9NUW8 4/20 0.49
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
CYP3A4 P08684 3/20 0.49
THRB P10828 2/20 0.49
RECQL P46063 2/20 0.49
GAA P10253 2/20 0.49
KDR P35968 2/20 0.49
HPGD P15428 2/20 0.49
HSD17B10 Q99714 2/20 0.49
USP2 O75604 1/20 0.49
POLB P06746 1/20 0.49
PKM P14618 1/20 0.49
APEX1 P27695 1/20 0.49
BLM P54132 1/20 0.49
MCL1 Q07820 1/20 0.49
TNF P01375 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28627930 0.85 GAA (0.58) ALDH1A1MAPTKDM4EGAAHPGD
SCHEMBL1185611 0.83 KMT2A (0.52) ALDH1A1MAPTKDM4ETDP1MEN1
SCHEMBL31656211 0.81 CYP3A4 (0.55) ALDH1A1MAPTKDM4ETDP1MEN1
SCHEMBL3288448 0.81 ADRB2 (0.52) ALDH1A1MAPTKDM4ECYP3A4GAA
SCHEMBL6177925 0.81 CASP1 (0.41) ALDH1A1MAPTKDM4ETDP1MEN1
SCHEMBL2616107 0.81 CYP3A4 (0.55) ALDH1A1MAPTKDM4ETDP1MEN1
SCHEMBL1186570 0.81 GAA (0.67) ALDH1A1MAPTKDM4ETDP1MEN1
SCHEMBL17713226 0.81 KDM4E (0.50) ALDH1A1MAPTKDM4ETDP1GAA
SCHEMBL6466459 0.81 CFD (0.45) ALDH1A1KDM4ETDP1KMT2AMCL1
SCHEMBL30638610 0.81 KDM4E (0.50) ALDH1A1MAPTKDM4ETDP1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250170265-A1 DIAZONIUM COMPOUNDS AND METHODS OF USE FOR DNA CLEAVAGE NEW YORK UNIVERSITY (US) 2025-05-29 US disclosed
US-20240336632-A1 NOVEL COMPOUND COMPRISING ESTER GROUP AND USES THEREOF KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR) 2024-10-10 US disclosed
EP-4382137-A1 NOVEL COMPOUND COMPRISING ESTER GROUP AND USES THEREOF Kyungpook National University Industry-Academic Cooperation Foundation (KR) 2024-06-12 EP disclosed
CN-114213435-B Preparation and application of bis- (10-deoxydihydroartemisinin) -phloroglucinol derivative 云白药征武科技(上海)有限公司 2023-03-21 CN disclosed
WO-2023014119-A1 NOVEL COMPOUND COMPRISING ESTER GROUP AND USES THEREOF 경북대학교 산학협력단 2023-02-09 WO disclosed
CN-113350296-B PAD4 inhibitor loaded by CRGD sequence peptide modified chitosan and preparation method and application thereof 首都医科大学 2022-07-15 CN disclosed
CN-114213435-A Preparation and application of bis- (10-deoxydihydroartemisinin) -phloroglucinol derivative 云白药征武科技(上海)有限公司 2022-03-22 CN disclosed
CN-113350296-A PAD4 inhibitor loaded by CRGD sequence peptide modified chitosan and preparation method and application thereof 首都医科大学 2021-09-07 CN disclosed
WO-2020191329-A1 ARAMID AMPHIPHILE SELF-ASSEMBLED NANOSTRUCTURES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2020-09-24 WO disclosed
US-20200298194-A1 ARAMID AMPHIPHILE SELF-ASSEMBLED NANOSTRUCTURES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2020-09-24 US disclosed
EP-0328585-B1 METABOLICALLY ACCEPTABLE POLYISOCYANATE ADHESIVES BIORESEARCH INC (US) 1994-09-07 EP disclosed
EP-0328585-A4 METABOLICALLY ACCEPTABLE POLYISOCYANATE ADHESIVES 1991-06-05 EP disclosed
EP-0328585-A1 METABOLICALLY ACCEPTABLE POLYISOCYANATE ADHESIVES BIORESEARCH INC. (US) 1989-08-23 EP disclosed
US-4829099-A SURGERY, POLYISOCYANATES, POLYISOTHIOCYANATES BIORESEARCH, INC. (US) 1989-05-09 US disclosed
WO-1989000589-A1 METABOLICALLY ACCEPTABLE POLYISOCYANATE ADHESIVES BIORESEARCH, INC. (US) 1989-01-26 WO disclosed
EP-0091240-B1 ENZYME DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BEECHAM GROUP PLC (GB) 1985-12-27 EP disclosed
US-4507232-A Peptide derivatives TAISHO PHARMACEUTICAL CO., LTD. (JP) 1985-03-26 US disclosed
US-4507283-A STREPTOKINASE-HUMAN PLASMINOGEN ACTIVATOR COMPLEX BLOCKED BY A 2- OR 4-AMINOBENZOYL GROUP; ANTICOAGULANT BEECHAM GROUP P.L.C. (GB) 1985-03-26 US disclosed
EP-0113996-A2 Peptide derivatives TAISHO PHARMACEUTICAL CO. LTD (JP) 1984-07-25 EP disclosed
EP-0091240-A2 Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them BEECHAM GROUP PLC (GB) 1983-10-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250170265-A1 DIAZONIUM COMPOUNDS AND METHODS OF USE FOR DNA CLEAVAGE OGG1, UNG, DNMT3A ALDH1A1 1349/4885MAPT 4621/4885KDM4E 1339/4885
US-20240336632-A1 NOVEL COMPOUND COMPRISING ESTER GROUP AND USES THEREOF PNLIP, CES1, AMY2A ALDH1A1 75/4885MAPT 4802/4885KDM4E 2406/4885
US-20200298194-A1 ARAMID AMPHIPHILE SELF-ASSEMBLED NANOSTRUCTURES ANXA6, ANXA1, ANXA11 ALDH1A1 3690/4885MAPT 1447/4885KDM4E 4448/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.