SCHEMBL8767798

SCHEMBL8767798

CCc1cc(C#N)ccc1Nc1c(N(CC)c2ccccc2)c(=O)c1=O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCC9 O60706 1/20 0.53
ABCC8 Q09428 1/20 0.53
KCNJ11 Q14654 1/20 0.53
KCNJ8 Q15842 1/20 0.53
CXCR2 P25025 9/20 0.45
MAPT P10636 1/20 0.36
CRHBP P24387 1/20 0.36
CRHR2 Q13324 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
GAA P10253 1/20 0.34
KDM4C Q9H3R0 1/20 0.34
APAF1 O14727 1/20 0.34
CASP3 P42574 1/20 0.34
CASP6 P55212 1/20 0.34
SENP8 Q96LD8 1/20 0.34
SENP7 Q9BQF6 1/20 0.34
SENP6 Q9GZR1 1/20 0.34
KCNN4 O15554 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8768157 0.89 CXCR2 (0.45) ABCC9ABCC8KCNJ11KCNJ8CXCR2
SCHEMBL8768875 0.82 CXCR2 (0.43) CXCR2MAPTCRHBPCRHR2NPSR1
SCHEMBL8767825 0.82 CXCR2 (0.44) CXCR2MAPTCRHBPCRHR2NPSR1
SCHEMBL8870947 0.74 ABCC9 (0.72) ABCC9ABCC8KCNJ11KCNJ8CXCR2
SCHEMBL8870945 0.74 ABCC9 (0.72) ABCC9ABCC8KCNJ11KCNJ8CXCR2
SCHEMBL8768638 0.74 ADAMTS5 (0.44) CXCR2CRHBPCRHR2KCNN4KCNA5
SCHEMBL8768608 0.72 RORC (0.40) CXCR2ALDH1A1KCNA5KDM1AADAMTS5
SCHEMBL4407734 0.72 ABCC9 (0.59) ABCC9ABCC8KCNJ11KCNJ8CXCR2
SCHEMBL8768956 0.70 ADAMTS5 (0.46) MAPTNPSR1KDM4EALDH1A1GAA
SCHEMBL6024203 0.69 ABCC9 (1.00) ABCC9ABCC8KCNJ11KCNJ8CXCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0789690-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-08-20 EP claimed
WO-1996014300-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-17 WO claimed
EP-0789690-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-08-20 EP disclosed
US-5532245-A TO REDUCE SMOOTH MUSCLE CONTRACTIONS; TREATMENT FOR URINARY INCONTINENCE, IRITABLE BOWEL SYNDROME AMERICAN HOME PRODUCTS CORPORATION (US) 1996-07-02 US disclosed
WO-1996014300-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-17 WO disclosed