SCHEMBL8768157

SCHEMBL8768157

CCN(c1ccccc1)c1c(Nc2ccc(C#N)cc2C)c(=O)c1=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 5/20 0.45
ABCC9 O60706 1/20 0.40
ABCC8 Q09428 1/20 0.40
KCNJ11 Q14654 1/20 0.40
KCNJ8 Q15842 1/20 0.40
MAPT P10636 1/20 0.36
CRHBP P24387 1/20 0.36
CRHR2 Q13324 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
TBXA2R P21731 3/20 0.35
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
GAA P10253 1/20 0.34
MAP2K1 Q02750 1/20 0.34
GSK3A P49840 1/20 0.34
GSK3B P49841 1/20 0.34
KDM4C Q9H3R0 1/20 0.34
APAF1 O14727 1/20 0.34
CASP3 P42574 1/20 0.34
CASP6 P55212 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8767798 0.89 ABCC9 (0.53) CXCR2ABCC9ABCC8KCNJ11KCNJ8
SCHEMBL8768875 0.82 CXCR2 (0.43) CXCR2MAPTCRHBPCRHR2NPSR1
SCHEMBL8767825 0.82 CXCR2 (0.44) CXCR2MAPTCRHBPCRHR2NPSR1
SCHEMBL8768608 0.74 RORC (0.40) CXCR2ALDH1A1GSK3AGSK3BKCNA5
SCHEMBL8768882 0.74 CXCR2 (0.50) CXCR2ABCC9ABCC8KCNJ11KCNJ8
SCHEMBL8768638 0.74 ADAMTS5 (0.44) CXCR2CRHBPCRHR2KCNN4KCNA5
SCHEMBL8768944 0.72 GAA (0.50) CXCR2ABCC9ABCC8KCNJ11KCNJ8
SCHEMBL8870610 0.71 ABCC9 (0.53) CXCR2ABCC9ABCC8KCNJ11KCNJ8
SCHEMBL8870608 0.71 ABCC9 (0.53) CXCR2ABCC9ABCC8KCNJ11KCNJ8
SCHEMBL8768956 0.70 ADAMTS5 (0.46) MAPTNPSR1KDM4EALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0789690-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-08-20 EP claimed
WO-1996014300-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-17 WO claimed
EP-0789690-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-08-20 EP disclosed
US-5532245-A TO REDUCE SMOOTH MUSCLE CONTRACTIONS; TREATMENT FOR URINARY INCONTINENCE, IRITABLE BOWEL SYNDROME AMERICAN HOME PRODUCTS CORPORATION (US) 1996-07-02 US disclosed
WO-1996014300-A1 N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES AMERICAN HOME PRODUCTS CORPORATION (US) 1996-05-17 WO disclosed