Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 5/20 | 0.73 |
| ▸ | TGM2 | P21980 | 5/20 | 0.73 |
| ▸ | MAOA | P21397 | 5/20 | 0.72 |
| ▸ | MAOB | P27338 | 5/20 | 0.72 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.68 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
| ▸ | MST1R | Q04912 | 1/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL134453 | 0.85 | TGM2 (1.00) | CES1TGM2MAOAMAOBCA12 | |
| SCHEMBL29506317 | 0.85 | TGM2 (1.00) | CES1TGM2MAOAMAOBCA12 | |
| SCHEMBL3521129 | 0.85 | MAOA (0.71) | CES1TGM2MAOAMAOBPDE3B | |
| SCHEMBL25367285 | 0.84 | MAOA (0.74) | CES1TGM2MAOAMAOBPDE3B | |
| SCHEMBL30588923 | 0.84 | MAOA (0.74) | CES1TGM2MAOAMAOBPDE3B | |
| SCHEMBL2789935 | 0.84 | MAOA (1.00) | CES1TGM2MAOAMAOBPDE3B | |
| Methane SCHEMBL27958656 | 0.83 | TGM2 (0.96) | CES1TGM2MAOAMAOBCA12 | |
| SCHEMBL1462357 | 0.83 | TGM2 (0.96) | CES1TGM2MAOAMAOBCA12 | |
| SCHEMBL29906173 | 0.82 | MAOB (0.72) | CES1TGM2MAOAMAOBPDE3B | |
| SCHEMBL2788548 | 0.82 | MAOB (0.72) | CES1TGM2MAOAMAOBPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595336-B2 | Isatine derivatives with neurotrophic activity | NEUROSEARCH A/S (DK) | 2009-09-29 | — | — | US | disclosed |
| US-7282511-B2 | Isatine derivatives with neurotrophic activity | NEUROSEARCH A/S (DK) | 2007-10-16 | — | — | US | disclosed |
| CN-1298704-C | Isatine derivatives with neurotrophic activity | NEUROSEARCH AS (DK) | 2007-02-07 | — | — | CN | disclosed |
| EP-1736468-A2 | Isatin derivatives with neurotrophic activity useful in the treatment of diseases mediated by the nerve growth factor (NGF) activation | NeuroSearch A/S (DK) | 2006-12-27 | — | — | EP | disclosed |
| US-20060229311-A1 | Isatine derivatives with neurotrophic activity | GROENBORG METTE | 2006-10-12 | — | — | US | disclosed |
| EP-1255734-B1 | ISATINE DERIVATIVES WITH NEUROTROPHIC ACTIVITY | NEUROSEARCH AS (DK) | 2006-06-21 | — | — | EP | disclosed |
| US-20030040518-A1 | Isatine derivatives with neurotrophic activity | ANIONA APS (DK) | 2003-02-27 | — | — | US | disclosed |
| CN-1395563-A | Isatine derivatives with neurotrophic activity | NEUROSEARCH AS (DK) | 2003-02-05 | — | — | CN | disclosed |
| EP-1255734-A1 | ISATINE DERIVATIVES WITH NEUROTROPHIC ACTIVITY | NeuroSearch A/S (DK) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001055110-A1 | ISATINE DERIVATIVES WITH NEUROTROPHIC ACTIVITY | NEUROSEARCH A/S (DK) | 2001-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229311-A1 | Isatine derivatives with neurotrophic activity | BDNF, NTRK2, NGF | CES1 4085/4885TGM2 4518/4885MAOA 620/4885 |
| US-20030040518-A1 | Isatine derivatives with neurotrophic activity | BDNF, NTRK2, NGF | CES1 4085/4885TGM2 4518/4885MAOA 620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.