SCHEMBL134453

SCHEMBL134453

O=C1Nc2ccc(Cl)cc2C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TGM2 P21980 6/20 1.00
CES1 P23141 5/20 1.00
MAOA P21397 4/20 0.67
MAOB P27338 4/20 0.67
CHEK1 O14757 1/20 0.56
LRRK2 Q5S007 2/20 0.55
PPOX P50336 1/20 0.55
CA12 O43570 1/20 0.55
CA1 P00915 1/20 0.55
CA2 P00918 1/20 0.55
CA9 Q16790 1/20 0.55
ALDH1A1 P00352 1/20 0.55
IDO1 P14902 1/20 0.54
TDO2 P48775 1/20 0.54
CAPN9 O14815 1/20 0.53
CASP3 P42574 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29506317 1.00 TGM2 (1.00) TGM2CES1MAOAMAOBCHEK1
SCHEMBL1462357 0.98 TGM2 (0.96) TGM2CES1MAOAMAOBCHEK1
Methane SCHEMBL27958656 0.98 TGM2 (0.96) TGM2CES1MAOAMAOBCHEK1
Nitrogen SCHEMBL29155961 0.96 TGM2 (0.92) TGM2CES1MAOAMAOBCHEK1
5-Fluoroisatin SCHEMBL11132105 0.89 CES1 (0.80) TGM2CES1MAOAMAOBCHEK1
Acetamide SCHEMBL8705155 0.88 TGM2 (0.77) TGM2CES1MAOAMAOBCHEK1
SCHEMBL31139641 0.87 CES1 (0.77) TGM2CES1MAOAMAOBCHEK1
Phenol SCHEMBL674629 0.87 CES1 (0.75) TGM2CES1MAOAMAOBCHEK1
SCHEMBL4370977 0.85 CES1 (0.73) TGM2CES1MAOAMAOBCHEK1
N-Methylpiperidine SCHEMBL4627711 0.84 CES1 (0.71) TGM2CES1MAOAMAOBLRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1034 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12594274-B2 Method for preparing a crystalline form of rabeximod Gulch Pharma AB (SE) 2026-04-07 US claimed
CN-117586485-A Sulfonated hydrocarbon polymer containing protecting group, synthesis method and application thereof in low-temperature proton exchange membrane fuel cell 中国科学院山西煤炭化学研究所 2024-02-23 CN claimed
US-20230227455-A1 METHOD FOR PREPARING A CRYSTALLINE FORM OF RABEXIMOD CYXONE AB (SE) 2023-07-20 US claimed
CN-111187233-B Polysubstituted benzothiazole and derivative and synthesis method thereof 湘潭大学 2023-05-30 CN claimed
EP-4165043-A1 METHOD FOR PREPARING A CRYSTALLINE FORM OF RABEXIMOD Cyxone AB (SE) 2023-04-19 EP claimed
CN-115698010-A Process for preparing a crystalline form of RABEXIMOD 赛克松公司 2023-02-03 CN claimed
CN-110128320-B Preparation method of 5-chloro-3-hydroxy-3-difluoroalkyl-indolin-2-one compound 上海应用技术大学 2022-06-07 CN claimed
CN-113912609-A Preparation method of natural alkaloid tryptanthrin and derivative thereof 江苏大学 2022-01-11 CN claimed
WO-2021250197-A1 METHOD FOR PREPARING A CRYSTALLINE FORM OF RABEXIMOD CYXONE AB (SE) 2021-12-16 WO claimed
CN-111574426-A Diamine monomer containing isoindigo structure and black polyimide synthesized from diamine monomer 湘潭大学 2020-08-25 CN claimed
US-20050262647-A1 Agent for dyeing fibers containing keratin HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 2005-12-01 US claimed
EP-1434557-B1 AGENT FOR THE COLORATION OF KERATIN-CONTAINING FIBERS HENKEL KGAA (DE) 2005-11-09 EP claimed
US-20050144740-A1 Agents used for dyeing keratinous fibers HENKEL AG & CO. KGAA (DE) 2005-07-07 US claimed
US-6743263-B1 Method for coloring keratin fibers HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2004-06-01 US claimed
US-6635090-B1 Dyeing method using a specific cationic derivative and a compound selected among a specific aldehyde, a specific ketone, a quinone and a di-imino-isoindoline or 3-amino-isoindolone derivative L'OREAL, S.A. (FR) 2003-10-21 US claimed
US-6458168-B1 Hair dyeing method using an aliphatic cationic amine and compound chosen from an aldehyde, a ketone, a quinone, a di-imino-isoindoline, and a 3-aminoisoindolone derivative L'OREAL S.A. (FR) 2002-10-01 US claimed
US-6451067-B1 HAIR DYE MIXTURE L'OREAL S.A. (FR) 2002-09-17 US claimed
US-6114540-A COMBINATORIAL LIBRARIES ARQULE, INC. (US) 2000-09-05 US claimed
US-5993971-A TRANSPARENT SUBSTRATE IS MADE OF A RESIN MATERIAL MAINLY CONSISTING OF A POLYCARBONATE RESIN THAT CONTAINS NO MORE THAN 4 WT % OF LOW MOLECULAR WEIGHT FRACTIONS IN ORDER TO AVOID A DOUBLE REFRACTION SONY CORPORATION (JP) 1999-11-30 US claimed
US-5021541-A Better flowability and moblability MITSUBISHI GAS CHEMICAL CO., LTD. (JP) 1991-06-04 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230227455-A1 METHOD FOR PREPARING A CRYSTALLINE FORM OF RABEXIMOD RAB2A, RAB9A, RAB10 TGM2 3772/4885CES1 3224/4885MAOA 1401/4885
US-12594274-B2 Method for preparing a crystalline form of rabeximod RAB10, RAB9A, RAB1A TGM2 4109/4885CES1 2881/4885MAOA 630/4885
US-20050144740-A1 Agents used for dyeing keratinous fibers KRT18, TUBB3, DSG1 TGM2 1512/4885CES1 3830/4885MAOA 2422/4885
US-20050262647-A1 Agent for dyeing fibers containing keratin KRT18, CKAP4, KRTCAP2 TGM2 1412/4885CES1 2379/4885MAOA 322/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.