Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247494 | 0.88 | CCKBR (0.49) | FAAHCNR2FFAR1EPHX2P2RX7 | |
| SCHEMBL2244033 | 0.81 | CCKBR (0.47) | FAAHCNR2EPHX2P2RX7KMT2A | |
| SCHEMBL2245261 | 0.76 | MMP12 (0.56) | FFAR1POLBGAAKMT2AALDH1A1 | |
| SCHEMBL3583723 | 0.75 | KLKB1 (0.54) | DHFR | |
| SCHEMBL2250529 | 0.73 | ADAMTS5 (0.64) | FFAR1POLBGAAKMT2ADHFR | |
| SCHEMBL2250713 | 0.73 | MMP12 (0.54) | FFAR1ALDH1A1DHFR | |
| SCHEMBL2247496 | 0.73 | HSD17B2 (0.40) | FAAHCNR2FFAR1KMT2AMRGPRX4 | |
| SCHEMBL2245262 | 0.73 | MRGPRX4 (0.53) | POLBGAAKMT2AALDH1A1MRGPRX4 | |
| SCHEMBL3595965 | 0.72 | KLKB1 (0.53) | FFAR1DHFR | |
| SCHEMBL6030433 | 0.70 | GPR132 (0.65) | POLBGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | FAAH 262/4885CNR2 2615/4885FFAR1 3780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.