SCHEMBL4380323

SCHEMBL4380323

C[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)C(=O)O

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADAMTS4 O75173 1/20 0.69
MMP2 P08253 8/20 0.66
MMP1 P03956 4/20 0.66
MMP9 P14780 4/20 0.66
MMP13 P45452 4/20 0.66
MMP3 P08254 3/20 0.66
MMP7 P09237 3/20 0.66
SLC1A3 P43003 1/20 0.60
SLC1A2 P43004 1/20 0.60
SLC1A1 P43005 1/20 0.60
CA2 P00918 4/20 0.54
CA12 O43570 3/20 0.54
CA9 Q16790 3/20 0.54
CA14 Q9ULX7 3/20 0.54
MMP8 P22894 3/20 0.52
MMP14 P50281 1/20 0.52
ADAMTS5 Q9UNA0 1/20 0.52
CA1 P00915 3/20 0.52
CA3 P07451 1/20 0.52
CA4 P22748 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3951681 1.00 ADAMTS4 (0.69) ADAMTS4MMP2MMP1MMP9MMP13
SCHEMBL3951678 1.00 ADAMTS4 (0.69) ADAMTS4MMP2MMP1MMP9MMP13
SCHEMBL3884130 0.86 MMP2 (0.57) ADAMTS4MMP2MMP1MMP9MMP13
SCHEMBL13890464 0.86 MMP2 (0.57) ADAMTS4MMP2MMP1MMP9MMP13
SCHEMBL3884127 0.86 MMP2 (0.57) ADAMTS4MMP2MMP1MMP9MMP13
SCHEMBL698908 0.84 ADAMTS4 (0.71) ADAMTS4MMP2MMP1MMP9MMP13
SCHEMBL698907 0.84 ADAMTS4 (0.71) ADAMTS4MMP2MMP1MMP9MMP13
SCHEMBL4975578 0.84 ADAMTS4 (0.71) ADAMTS4MMP2MMP1MMP9MMP13
SCHEMBL702794 0.84 ADAMTS4 (0.81) ADAMTS4MMP2MMP1MMP9MMP13
SCHEMBL790069 0.84 ADAMTS4 (0.81) ADAMTS4MMP2MMP1MMP9MMP13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3653607-B1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE REUTER CHEMISCHE APPBAU E K (DE) 2023-10-18 EP claimed
US-11472770-B2 Process for the preparation of enantiomerically enriched 3-aminopiperidine REUTER CHEMISCHE APPARATEBAU KG 2022-10-18 US claimed
EP-3653607-A2 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE Reuter Chemische Apparatenbau e.K. (DE) 2020-05-20 EP claimed
US-20200087257-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE REUTER CHEMISCHE APPARATEBAU KG (DE) 2020-03-19 US claimed
US-20160251311-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE REUTER CHEMISCHE APPARATEBAU KG (DE) 2016-09-01 US claimed
EP-2958894-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE Reuter Chemische Apparatebau KG (DE) 2015-12-30 EP claimed
CN-105102430-A Process for the preparation of enantiomerically enriched 3-aminopiperidine REUTER CHEMISCHE APPBAU KG 2015-11-25 CN claimed
WO-2014128139-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE REUTER CHEMISCHE APPARATEBAU KG (DE) 2014-08-28 WO claimed
US-11897843-B2 Process for the preparation of enantiomerically enriched 3-aminopiperidine REUTER CHEMISCHE APPARATEBAU KG 2024-02-13 US disclosed
EP-4289819-A2 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE Reuter Chemische Apparatebau e.K. (DE) 2023-12-13 EP disclosed
EP-3653607-B1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE REUTER CHEMISCHE APPBAU E K (DE) 2023-10-18 EP disclosed
US-20230008387-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE REUTER CHEMISCHE APPARATEBAU KG (DE) 2023-01-12 US disclosed
US-11472770-B2 Process for the preparation of enantiomerically enriched 3-aminopiperidine REUTER CHEMISCHE APPARATEBAU KG 2022-10-18 US disclosed
EP-3653607-A2 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE Reuter Chemische Apparatenbau e.K. (DE) 2020-05-20 EP disclosed
EP-1820798-B1 7-MEMBERED RING COMPOUND, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF DAIICHI SANKYO CO LTD (JP) 2012-08-22 EP disclosed
EP-2463268-A1 Aminomethyl-substituted aromatic acids as intermediates for the preparation of chymase inhibiting 1,4-diazepan-2,5-dione compounds Daiichi Sankyo Company, Limited (JP) 2012-06-13 EP disclosed
US-20090253683-A1 7-MEMBERED RING COMPOUND AND METHOD OF PRODUCTION AND PHARMACEUTICAL APPLICATION THEREOF ASUBIO PHARMA CO., LTD (JP) 2009-10-08 US disclosed
US-20090111796-A1 7-membered ring compound and method of production and pharmaceutical application thereof DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-04-30 US disclosed
EP-2025672-A1 SEVEN-MEMBERED RING COMPOUND, PRODUCTION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF Asubio Pharma Co., Ltd. (JP) 2009-02-18 EP disclosed
EP-1820798-A1 7-MEMBERED RING COMPOUND, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF Asubio Pharma Co., Ltd. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230008387-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE NPEPPS, AASDHPPT, DNPEP ADAMTS4 4756/4885MMP2 4358/4885MMP1 4007/4885
US-11472770-B2 Process for the preparation of enantiomerically enriched 3-aminopiperidine NPEPPS, AASDHPPT, DNPEP ADAMTS4 4756/4885MMP2 4358/4885MMP1 4007/4885
US-11897843-B2 Process for the preparation of enantiomerically enriched 3-aminopiperidine NPEPPS, AASDHPPT, DNPEP ADAMTS4 4764/4885MMP2 4338/4885MMP1 4053/4885
US-20090111796-A1 7-membered ring compound and method of production and pharmaceutical application thereof CMA1, CPA3, SI ADAMTS4 153/4885MMP2 64/4885MMP1 111/4885
US-20200087257-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE NPEPPS, AASDHPPT, DNPEP ADAMTS4 4756/4885MMP2 4358/4885MMP1 4007/4885
US-20090253683-A1 7-MEMBERED RING COMPOUND AND METHOD OF PRODUCTION AND PHARMACEUTICAL APPLICATION THEREOF CMA1, CPA3, SI ADAMTS4 153/4885MMP2 64/4885MMP1 111/4885
US-20160251311-A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED 3-AMINOPIPERIDINE NPEPPS, AASDHPPT, DNPEP ADAMTS4 4743/4885MMP2 4285/4885MMP1 3943/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.