Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MMP2 | P08253 | 7/20 | 0.50 |
| ▸ | MMP9 | P14780 | 7/20 | 0.50 |
| ▸ | MMP1 | P03956 | 6/20 | 0.50 |
| ▸ | MMP13 | P45452 | 6/20 | 0.50 |
| ▸ | MMP3 | P08254 | 4/20 | 0.50 |
| ▸ | MMP14 | P50281 | 4/20 | 0.50 |
| ▸ | MMP8 | P22894 | 3/20 | 0.50 |
| ▸ | MMP16 | P51512 | 2/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | TARS1 | P26639 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350929 | 0.83 | LMNA (0.51) | LMNAHTTMMP2MMP9MMP1 | |
| SCHEMBL7345647 | 0.79 | LMNA (0.47) | LMNAHTTMMP2MMP9MMP1 | |
| SCHEMBL8189066 | 0.77 | SOS1 (0.53) | LMNAHTTMMP2MMP9MMP1 | |
| SCHEMBL1800017 | 0.76 | MMP2 (0.44) | LMNAHTTMMP2MMP9MMP1 | |
| SCHEMBL7348180 | 0.75 | MMP13 (0.44) | LMNAHTTMMP2MMP9MMP1 | |
| SCHEMBL4371638 | 0.74 | PTGES (0.48) | LMNAHTTMMP2MMP9MMP1 | |
| SCHEMBL4371642 | 0.74 | PTGES (0.48) | LMNAHTTMMP2MMP9MMP1 | |
| SCHEMBL1798546 | 0.73 | MMP9 (0.67) | HTTMMP2MMP9MMP1MMP13 | |
| SCHEMBL1798547 | 0.73 | MMP9 (0.67) | HTTMMP2MMP9MMP1MMP13 | |
| SCHEMBL6757287 | 0.73 | MMP1 (0.46) | LMNAHTTMMP2MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143386-A1 | Human adam-10 inhibitors | EXELIXIS, INC. | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143386-A1 | Human adam-10 inhibitors | ADAM10, ADAM12, CASP10 | LMNA 3464/4885HTT 3299/4885MMP2 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.