SCHEMBL4384483

SCHEMBL4384483

N#Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(N)n3)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30674410 1.00 HSD11B1 (1.00) HSD11B1
SCHEMBL12640446 0.84 HSD11B1 (1.00) HSD11B1
SCHEMBL19248162 0.81 HSD11B1 (1.00) HSD11B1
SCHEMBL4378537 0.81 HSD11B1 (1.00) HSD11B1
SCHEMBL788804 0.81 HSD11B1 (0.68) HSD11B1
SCHEMBL4392304 0.81 HSD11B1 (1.00) HSD11B1
SCHEMBL13634947 0.80 HSD11B1 (0.67) HSD11B1
SCHEMBL23815240 0.79 HSD11B1 (0.83) HSD11B1
SCHEMBL4377098 0.79 HSD11B1 (1.00) HSD11B1
SCHEMBL13635045 0.79 HSD11B1 (1.00) HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119104707-A Method for in-vitro evaluation of cosmetic raw materials and nerve beautifying effect of finished product 广东迪美新材料科技有限公司 2024-12-10 CN claimed
WO-2021180643-A1 HSD11B1 INHIBITORS FOR USE IN IMMUNOTHERAPY AND USES THEREOF UNIVERSITE DE GENEVE (CH) 2021-09-16 WO claimed
EP-3878446-A1 HSD11B1 INHIBITORS FOR USE IN IMMUNOTHERAPY AND USES THEREOF UNIVERSITE DE GENEVE (CH) 2021-09-15 EP claimed
US-20260137658-A1 METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS SPARROW PHARMACEUTICALS INC (US) 2026-05-21 US disclosed
US-20260137656-A1 METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS SPARROW PHARMACEUTICALS INC (US) 2026-05-21 US disclosed
US-20260137657-A1 METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS SPARROW PHARMACEUTICALS INC (US) 2026-05-21 US disclosed
US-20260137659-A1 METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS SPARROW PHARMACEUTICALS INC (US) 2026-05-21 US disclosed
US-20260137660-A1 METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS SPARROW PHARMACEUTICALS INC (US) 2026-05-21 US disclosed
US-20250319072-A1 METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS SPARROW PHARMACEUTICALS INC (US) 2025-10-16 US disclosed
US-12329745-B2 Methods and compositions for treating glucocorticoid excess SPARROW PHARMACEUTICALS, INC. (US) 2025-06-17 US disclosed
WO-2025068686-A1 TREATMENT FOR BATTEN DISEASE THE ROYAL VETERINARY COLLEGE (GB) 2025-04-03 WO disclosed
US-20170232007-A1 METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS SANNA PIETRO PAOLO (US) 2017-08-17 US disclosed
WO-2016164413-A1 PHARMACEUTICAL COMPOSITIONS FOR COMBINATION THERAPY INTERCEPT PHARMACEUTICALS, INC. (US) 2016-10-13 WO disclosed
US-8871208-B2 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof ABBVIE INC. (US) 2014-10-28 US disclosed
US-20110159005-A1 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) INHIBITORS AND USES THEREOF ABBOTT LABORATORIES (US) 2011-06-30 US disclosed
EP-1893609-B1 N-(PYRIDIN-2-YL)-SULFONAMIDE DERIVATIVES PFIZER (US) 2009-11-18 EP disclosed
US-7462634-B2 N-(pyridin-2-yl)-sulfonamide derivatives AGOURON PHARMACEUTICALS, INC. (US) 2008-12-09 US disclosed
EP-1893609-A1 N-(PYRIDIN-2-YL)-SULFONAMIDE DERIVATIVES Pfizer, Inc. (US) 2008-03-05 EP disclosed
US-20070072914-A1 N-(pyridin-2-yl)-sulfonamide derivatives AGOURON PHARMACEUTICALS, INC. 2007-03-29 US disclosed
WO-2006134467-A1 N-(PYRIDIN-2-YL)-SULFONAMIDE DERIVATIVES PFIZER INC. (US) 2006-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250319072-A1 METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS HSD11B1, HSD17B1, HSD3B1 HSD11B1 1/4885
US-20260137656-A1 METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS NR3C1, NR3C2, SHBG HSD11B1 4/4885
US-20260137657-A1 METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS NR3C2, NR3C1, MC2R HSD11B1 4/4885
US-12329745-B2 Methods and compositions for treating glucocorticoid excess HSD11B1, HSD17B1, HSD3B1 HSD11B1 1/4885
US-20170232007-A1 METHODS AND COMPOSITIONS FOR TREATING ALCOHOL USE DISORDERS HSD3B1, HSD11B1, HSD3B2 HSD11B1 2/4885
US-20260137660-A1 METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS NR3C1, NR3C2, SHBG HSD11B1 4/4885
US-20260137659-A1 METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS NR3C2, NR3C1, MC2R HSD11B1 4/4885
US-20110159005-A1 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) INHIBITORS AND USES THEREOF HSD11B1, HSD17B1, HSD11B2 HSD11B1 1/4885
US-20260137658-A1 METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS NR3C1, NR3C2, NR5A1 HSD11B1 5/4885
US-20070072914-A1 N-(pyridin-2-yl)-sulfonamide derivatives HSD11B1, HSD3B1, HSD11B2 HSD11B1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.