Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399381 | 0.85 | MAPT (0.60) | MAPTDGAT1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2491808 | 0.83 | MAPT (0.67) | MAPTSMN1; SMN2ALDH1A1POLBKMT2A | |
| SCHEMBL10379966 | 0.83 | USP14 (0.44) | DGAT1ALDH1A1POLBKMT2AKDM4E | |
| SCHEMBL4396258 | 0.83 | GAA (0.42) | DGAT1SMN1; SMN2ALDH1A1POLBKMT2A | |
| SCHEMBL4399969 | 0.81 | MAPT (0.70) | MAPTSMN1; SMN2LMNAALDH1A1POLB | |
| SCHEMBL25169812 | 0.81 | MAPT (0.48) | MAPTDGAT1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL26123468 | 0.80 | GPR119 (0.48) | DGAT1SMN1; SMN2L3MBTL1KMT2AKDM4E | |
| SCHEMBL14511129 | 0.80 | MAPT (0.53) | MAPTDGAT1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL10113807 | 0.79 | MAPT (0.45) | MAPTLMNAALDH1A1POLBL3MBTL1 | |
| SCHEMBL25455655 | 0.78 | DGAT1 (0.37) | DGAT1POLBKMT2AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258304-B2 | N-aryl piperidine substituted biphenylcarboxamides | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-09-04 | — | — | US | disclosed |
| US-20090156623-A1 | N-ARYL PIPERIDINE SUBSTITUTED BIPHENYLCARBOXAMIDES | MEERPOEL LIEVEN | 2009-06-18 | — | — | US | disclosed |
| EP-1536796-B1 | N-ARYL PIPERIDINE SUBSTITUTED BIPHENYLCARBOXAMIDES AS INHIBITORS OF APOLIPOPROTEIN B SECRETION | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-13 | — | — | EP | disclosed |
| US-20060040989-A1 | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-02-23 | — | — | US | disclosed |
| EP-1536796-A1 | N-ARYL PIPERIDINE SUBSTITUTED BIPHENYLCARBOXAMIDES AS INHIBITORS OF APOLIPOPROTEIN B SECRETION | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004017969-A1 | N-ARYL PIPERIDINE SUBSTITUTED BIPHENYLCARBOXAMIDES AS INHIBITORS OF APOLIPOPROTEIN B SECRETION | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156623-A1 | N-ARYL PIPERIDINE SUBSTITUTED BIPHENYLCARBOXAMIDES | LIPC, PNLIP, GPR119 | MAPT 4498/4885DGAT1 395/4885SMN1; SMN2 3213/4885 |
| US-20060040989-A1 | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion | APOB, PNLIP, LPL | MAPT 4272/4885DGAT1 724/4885SMN1; SMN2 3421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.