Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10379966 | 0.87 | USP14 (0.44) | GAAKDM4ETSHRHSD17B10PTPN11 | |
| SCHEMBL26123468 | 0.84 | GPR119 (0.48) | GAAKDM4ETSHRHSD17B10DGAT1 | |
| SCHEMBL2145424 | 0.84 | DGAT1 (0.49) | GAAKDM4ETSHRHSD17B10DGAT1 | |
| SCHEMBL4389301 | 0.83 | MAPT (0.46) | GAAKDM4ETSHRHSD17B10DGAT1 | |
| SCHEMBL14669277 | 0.83 | OPRK1 (0.43) | GAAKDM4ETSHRHSD17B10DGAT1 | |
| SCHEMBL595764 | 0.82 | PTPN11 (0.59) | GAAKDM4EPTPN11POLBKMT2A | |
| SCHEMBL14511132 | 0.80 | PIK3CA (0.46) | DGAT1PARP14JAK2JAK1TYK2 | |
| SCHEMBL25455655 | 0.79 | DGAT1 (0.37) | GAAKDM4ETSHRHSD17B10PTPN11 | |
| SCHEMBL12515725 | 0.79 | OPRK1 (0.40) | DGAT1PARP14JAK2JAK1TYK2 | |
| SCHEMBL132391 | 0.79 | LGMN (0.48) | GAAKDM4ETSHRPARP14ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258304-B2 | N-aryl piperidine substituted biphenylcarboxamides | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-09-04 | — | — | US | disclosed |
| US-20090156623-A1 | N-ARYL PIPERIDINE SUBSTITUTED BIPHENYLCARBOXAMIDES | MEERPOEL LIEVEN | 2009-06-18 | — | — | US | disclosed |
| EP-1536796-B1 | N-ARYL PIPERIDINE SUBSTITUTED BIPHENYLCARBOXAMIDES AS INHIBITORS OF APOLIPOPROTEIN B SECRETION | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-13 | — | — | EP | disclosed |
| US-20060040989-A1 | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-02-23 | — | — | US | disclosed |
| EP-1536796-A1 | N-ARYL PIPERIDINE SUBSTITUTED BIPHENYLCARBOXAMIDES AS INHIBITORS OF APOLIPOPROTEIN B SECRETION | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004017969-A1 | N-ARYL PIPERIDINE SUBSTITUTED BIPHENYLCARBOXAMIDES AS INHIBITORS OF APOLIPOPROTEIN B SECRETION | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156623-A1 | N-ARYL PIPERIDINE SUBSTITUTED BIPHENYLCARBOXAMIDES | LIPC, PNLIP, GPR119 | GAA 141/4885KDM4E 944/4885TSHR 1847/4885 |
| US-20060040989-A1 | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion | APOB, PNLIP, LPL | GAA 215/4885KDM4E 2309/4885TSHR 2048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.