SCHEMBL439674

SCHEMBL439674

Cn1cc(C(=O)Cl)c(C(F)F)n1

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 1/20 0.35
CYP11B1 P15538 1/20 0.35
CYP11B2 P19099 1/20 0.35
LMNA P02545 1/20 0.35
POLB P06746 1/20 0.35
IRAK4 Q9NWZ3 11/20 0.34
ACACB O00763 1/20 0.34
GAA P10253 2/20 0.33
ALDH1A1 P00352 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL38654637 0.98 KLKB1 (0.34) KLKB1CYP11B1CYP11B2LMNAPOLB
SCHEMBL8932291 0.94 CYP11B1 (0.33) KLKB1CYP11B1CYP11B2LMNAPOLB
SCHEMBL9266924 0.89 LMNA (0.35) LMNAPOLBIRAK4ACACBGAA
SCHEMBL3251664 0.85 GAA (0.34) LMNAPOLBGAAALDH1A1SMN1; SMN2
SCHEMBL20141 0.84 IRAK4 (0.35) KLKB1CYP11B1CYP11B2LMNAPOLB
SCHEMBL14010542 0.84 LMNA (0.35) KLKB1CYP11B1CYP11B2LMNAPOLB
SCHEMBL11893139 0.84 RAB9A (0.34) LMNAPOLBGAAALDH1A1SMN1; SMN2
SCHEMBL21326127 0.83 KLKB1 (0.34) KLKB1CYP11B1CYP11B2LMNAPOLB
SCHEMBL22234827 0.83 ALDH1A1 (0.40) KLKB1CYP11B1CYP11B2LMNAPOLB
SCHEMBL22843773 0.83 IRAK4 (0.40) KLKB1LMNAPOLBIRAK4ACACB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 497 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12509417-B2 Enantioselective process SYNGENTA CROP PROTECTION AG (CH) 2025-12-30 US claimed
US-12491503-B2 Hydrogenation process of oxime derivatives SYNGENTA CROP PROTECTION AG (CH) 2025-12-09 US claimed
WO-2025074339-A1 A PROCESS FOR PREPARATION OF CARBOXAMIDE COMPOUNDS AND INTERMEDIATES THEREOF UPL LIMITED (IN) 2025-04-10 WO claimed
CN-119056375-B Preparation method of fluxapyroxad 天津凯莱英医药科技发展有限公司 2025-03-07 CN claimed
CN-119285548-A Fluoconazole fungus Process for the preparation of amides 湖南化工研究院有限公司 2025-01-10 CN claimed
CN-113195460-B Enantioselective process 先正达农作物保护股份公司 2024-07-19 CN claimed
CN-118324696-A Key raw material for detecting bixafen as well as preparation method and application thereof 福建省农业科学院农业质量标准与检测技术研究所 2024-07-12 CN claimed
EP-3877394-B1 HYDROGENATION PROCESS OF OXIME DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2024-06-26 EP claimed
CN-116162063-B Pyrazole formylhydroxylamine compound containing bisamide bond, and preparation method and application thereof 浙江工业大学 2024-05-28 CN claimed
CN-116239533-B Difluoromethyl pyrazole carboxamide compounds containing benzoate (amide), preparation method and application thereof 浙江工业大学 2024-05-24 CN claimed
CN-114957123-B 3- (difluoromethyl) -pyrazole-4-carboxylic ester derivative and preparation method and application thereof 浙江工业大学 2023-11-28 CN claimed
EP-3877372-B1 ENANTIOSELECTIVE REDUCTION OF OXIME-DERIVATIVES INVOLVING IRIDIUM BASED CATALYSTS SYNGENTA CROP PROTECTION AG (CH) 2023-08-02 EP claimed
CN-116239533-A Difluoromethyl pyrazole carboxamide compounds containing benzoate (amide), preparation method and application thereof 浙江工业大学 2023-06-09 CN claimed
CN-116178264-A Synthesis method of bixafen 西安近代化学研究所 2023-05-30 CN claimed
CN-116162063-A Pyrazole formylhydroxylamine compound containing bisamide bond, and preparation method and application thereof 浙江工业大学 2023-05-26 CN claimed
CN-114957123-A 3- (difluoromethyl) -pyrazole-4-carboxylic ester derivative and preparation method and application thereof 浙江工业大学 2022-08-30 CN claimed
US-20220106263-A1 ENANTIOSELECTIVE PROCESS SYNGENTA CROP PROTECTION AG (CH) 2022-04-07 US claimed
CN-108610290-B Preparation method of fluxapyroxad 武汉工程大学 2020-04-24 CN claimed
CN-110117256-A A kind of synthetic method of biphenyl pyrrole bacterium amine 苪城县斯普伦迪生物工程有限公司 2019-08-13 CN claimed
EP-2253623-A1 New crystal form of a pyrazole fungicide Syngenta Participations AG. (CH) 2010-11-24 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12509417-B2 Enantioselective process HCCS, AOC3, CYP8B1 KLKB1 4787/4885CYP11B1 88/4885CYP11B2 100/4885
US-20220106263-A1 ENANTIOSELECTIVE PROCESS CYP11B2, CYP2E1, CYP2F1 KLKB1 4338/4885CYP11B1 6/4885CYP11B2 1/4885
US-12491503-B2 Hydrogenation process of oxime derivatives HMOX2, HAO2, PRDX5 KLKB1 4480/4885CYP11B1 119/4885CYP11B2 44/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.