Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | WNT1 | P04628 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4403763 | 0.94 | TLR9 (0.42) | TLR9GSK3BACKR3DYRK1ACD274 | |
| SCHEMBL4410357 | 0.90 | GSK3B (0.40) | TLR9GSK3BACKR3DYRK1ACD274 | |
| SCHEMBL4550682 | 0.89 | GSK3B (0.39) | TLR9GSK3BACKR3DYRK1ACD274 | |
| SCHEMBL4396992 | 0.89 | KMT2A (0.41) | ACKR3SIGMAR1DYRK1AHTR4 | |
| SCHEMBL914725 | 0.87 | TLR9 (0.44) | TLR9GSK3BACKR3SIGMAR1DYRK1A | |
| SCHEMBL4405570 | 0.87 | TLR7 (0.43) | TLR9SIGMAR1DYRK1AHTR4 | |
| SCHEMBL4396410 | 0.87 | L3MBTL1 (0.40) | DYRK1AWNT1 | |
| SCHEMBL4396337 | 0.86 | HTR7 (0.43) | HTR7 | |
| SCHEMBL4396457 | 0.85 | HRH3 (0.42) | HTR7 | |
| SCHEMBL4410349 | 0.85 | HRH3 (0.42) | HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |