Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 7/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | TLR4 | O00206 | 1/20 | 0.39 |
| ▸ | TLR3 | O15455 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4396992 | 0.90 | KMT2A (0.41) | DYRK1AHTR4SIGMAR1KMT2AKDM4E | |
| SCHEMBL4396410 | 0.88 | L3MBTL1 (0.40) | DYRK1AKDM4EHPGDHTTHSD17B10 | |
| SCHEMBL4401901 | 0.88 | HTR4 (0.46) | SMN1; SMN2NPSR1HTR4SIGMAR1KMT2A | |
| SCHEMBL4396337 | 0.87 | HTR7 (0.43) | SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL4396957 | 0.87 | TLR9 (0.42) | TLR9DYRK1AHTR4SIGMAR1 | |
| SCHEMBL913724 | 0.87 | TLR7 (0.50) | TLR7TLR9TLR8DYRK1ASMN1; SMN2 | |
| SCHEMBL4406646 | 0.86 | TSHR (0.42) | TLR9HTR4SIGMAR1KMT2AKDM4E | |
| SCHEMBL4394199 | 0.86 | CHRM3 (0.41) | DYRK1AHTR4RAD52 | |
| SCHEMBL4396457 | 0.85 | HRH3 (0.42) | SMN1; SMN2NPSR1KMT2AKDM4EHPGD | |
| SCHEMBL4410349 | 0.85 | HRH3 (0.42) | SMN1; SMN2NPSR1KMT2AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-B1 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2009-12-23 | — | — | EP | claimed |