Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.57 |
| ▸ | NOS2 | P35228 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31135815 | 1.00 | NOS3 (0.57) | NOS3NOS2ADRB1MAPK1ADRB2 | |
| Formaldehyde SCHEMBL27676979 | 0.94 | NOS3 (0.52) | NOS3NOS2ADRB1MAPK1ADRB2 | |
| SCHEMBL8433719 | 0.77 | KIF11 (0.38) | NOS3NOS2KIF11ALDH1A1GAA | |
| SCHEMBL810884 | 0.76 | NOS3 (0.61) | NOS3NOS2ADRB1MAPK1ADRB2 | |
| SCHEMBL2327508 | 0.74 | NOS3 (0.59) | NOS3NOS2ADRB1MAPK1ADRB2 | |
| SCHEMBL29518423 | 0.74 | NOS3 (0.59) | NOS3NOS2ADRB1MAPK1ADRB2 | |
| SCHEMBL607015 | 0.74 | NOS3 (0.59) | NOS3NOS2ADRB1MAPK1ADRB2 | |
| SCHEMBL119912 | 0.73 | NOS3 (0.57) | NOS3NOS2ADRB1MAPK1ADRB2 | |
| SCHEMBL1507293 | 0.73 | NOS3 (0.57) | NOS3NOS2ADRB1MAPK1ADRB2 | |
| SCHEMBL1660106 | 0.73 | NOS3 (0.57) | NOS3NOS2ADRB1MAPK1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3686203-A1 | 4-SULFUR SUBSTITUTED PODOPHYLLOTOXIN DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF | Tang, Yajie (CN) | 2020-07-29 | — | — | EP | claimed |
| CN-111454308-A | Teniposide derivative and preparation method and application thereof | 湖北工业大学 | 2020-07-28 | — | — | CN | claimed |
| US-20200216449-A1 | 4-Sulfur Substituted Podophyllotoxin Derivative and Preparation Method Therefor and Use Thereof | Tang, YaJie (CN) | 2020-07-09 | — | — | US | claimed |
| US-20200216462-A1 | 4-Sulfur Substituted Podophyllotoxin Derivative and Preparation Method Therefor and Use Thereof | Tang, YaJie (CN) | 2020-07-09 | — | — | US | claimed |
| CN-108285456-A | 4- sulphur replaces podophyllotoxin derivative and its preparation method and application | 汤亚杰 | 2018-07-17 | — | — | CN | claimed |
| US-20240400502-A1 | SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME | UNIV QUEENSLAND (AU) | 2024-12-05 | — | — | US | disclosed |
| US-11845715-B2 | — | — | 2023-12-19 | — | — | US | disclosed |
| US-11845715-B2 | — | — | 2023-12-19 | — | — | US | disclosed |
| US-11845715-B2 | — | — | 2023-12-19 | — | — | US | disclosed |
| US-20230365592-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. | 2023-11-16 | — | — | US | disclosed |
| EP-3686203-B1 | 4-SULFUR SUBSTITUTED PODOPHYLLOTOXIN DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF | TANG YAJIE (CN) | 2023-10-25 | — | — | EP | disclosed |
| EP-3686203-B1 | 4-SULFUR SUBSTITUTED PODOPHYLLOTOXIN DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF | TANG YAJIE (CN) | 2023-10-25 | — | — | EP | disclosed |
| EP-1179011-A1 | GLYCOPEPTIDE ANTIBIOTICS, COMBINATORIAL LIBRARIES OF GLYCOPEPTIDE ANTIBIOTICS AND METHODS OF PRODUCING SAME | Princeton University (US) | 2002-02-13 | — | — | EP | disclosed |
| EP-1095058-A1 | GLYCOPEPTIDE ANTIBIOTICS, COMBINATORIAL LIBRARIES OF GLYCOPEPTIDE ANTIBIOTICS AND METHODS OF PRODUCING SAME | Princeton University (US) | 2001-05-02 | — | — | EP | disclosed |
| US-6169181-B1 | HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY | 2001-01-02 | — | — | US | disclosed |
| WO-2000069892-A1 | GLYCOPEPTIDE ANTIBIOTICS, COMBINATORIAL LIBRARIES OF GLYCOPEPTIDE ANTIBIOTICS AND METHODS OF PRODUCING SAME | PRINCETON UNIVERSITY (US) | 2000-11-23 | — | — | WO | disclosed |
| WO-2000004044-A1 | GLYCOPEPTIDE ANTIBIOTICS, COMBINATORIAL LIBRARIES OF GLYCOPEPTIDE ANTIBIOTICS AND METHODS OF PRODUCING SAME | PRINCETON UNIVERSITY (US) | 2000-01-27 | — | — | WO | disclosed |
| US-5852195-A | Pyranone compounds useful to treat retroviral infections | PHARMACIA & UPJOHN COMPANY (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0758327-A1 | PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1997-02-19 | — | — | EP | disclosed |
| WO-1995030670-A2 | PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11845715-B2 | — | NLRP3, PYCARD, NOD1 | NOS3 782/4885NOS2 984/4885ADRB1 3387/4885 |
| US-20240400502-A1 | SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME | NLRP3, PYCARD, IAPP | NOS3 1173/4885NOS2 1762/4885ADRB1 2820/4885 |
| US-20230365592-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | PAH, KDM8, PHF8 | NOS3 618/4885NOS2 1134/4885ADRB1 2521/4885 |
| US-20200216462-A1 | 4-Sulfur Substituted Podophyllotoxin Derivative and Preparation Method Therefor and Use Thereof | WEE1, WEE2, DHFR | NOS3 3215/4885NOS2 2812/4885ADRB1 4016/4885 |
| US-20200216449-A1 | 4-Sulfur Substituted Podophyllotoxin Derivative and Preparation Method Therefor and Use Thereof | TPMT, WEE1, DHFR | NOS3 3021/4885NOS2 2287/4885ADRB1 4018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.