SCHEMBL4403646

SCHEMBL4403646

CCC1O[C@H](OCc2ccccc2)C(OO[C@@H]2C(OC(=O)c3ccccc3)[C@@H](O[C@@H]3C(OC(=O)c4ccccc4)[C@@H](O[C@@H]4C(OC(=O)c5ccccc5)COC(COC(=O)c5ccccc5)[C@H]4C)OC(COC(=O)c4ccccc4)[C@H]3C)OC(COC(=O)c3ccccc3)[C@H]2C)[C@@H](C)[C@@H]1C

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ SLC6A2 P23975 2/20 0.36
▸ FGF2 P09038 3/20 0.34
▸ FGF1 P05230 2/20 0.34
▸ VEGFA P15692 2/20 0.34
▸ HPSE Q9Y251 2/20 0.34
▸ NT5E P21589 1/20 0.34
▸ BCHE P06276 4/20 0.33
▸ MDK P21741 1/20 0.33
▸ PTPN1 P18031 1/20 0.32
▸ ANTXR2 P58335 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4404462 0.88 LMNA (0.42) SLC6A2FGF2FGF1VEGFAHPSE
SCHEMBL4407362 0.88 FGF2 (0.40) SLC6A2FGF2FGF1VEGFAHPSE
SCHEMBL4404804 0.87 BCHE (0.41) BCHEPTPN1ANTXR2
SCHEMBL4402910 0.85 FGF2 (0.41) SLC6A2FGF2FGF1VEGFAHPSE
SCHEMBL4403642 0.84 FGF1 (0.38) FGF2FGF1VEGFAHPSENT5E
SCHEMBL4409916 0.83 PTPN1 (0.38) BCHEPTPN1ANTXR2
SCHEMBL4402915 0.82 FGF1 (0.39) SLC6A2FGF2FGF1VEGFAHPSE
SCHEMBL4402919 0.82 PTPN1 (0.38) BCHEPTPN1
SCHEMBL26562238 0.76 PAX8 (0.38) PTPN1
SCHEMBL15965619 0.76 TYMP (0.40) SLC6A2FGF2FGF1VEGFAHPSE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8173606-B2 Sulfated oligosaccharide derivatives PROGEN PHARMACEUTICALS LIMITED (AU) 2012-05-08 — — US disclosed
US-20110130354-A1 SULFATED OLIGOSACCHARIDE DERIVATIVES PROGEN PHARMACEUTICALS LIMITED (AU) 2011-06-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110130354-A1 SULFATED OLIGOSACCHARIDE DERIVATIVES HPSE, APOB, LIPG SLC6A2 4286/4885FGF2 166/4885FGF1 348/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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