Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 6/20 | 0.45 |
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 3/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4415213 | 0.89 | RAF1 (0.45) | RAF1BRAFMAPTMEN1KMT2A | |
| SCHEMBL5602348 | 0.88 | HTT (0.41) | RAF1BRAFMAPTUSP30MAPK14 | |
| SCHEMBL4551800 | 0.86 | MEN1 (0.46) | RAF1MAPTMEN1KMT2ARXFP1 | |
| SCHEMBL4551944 | 0.85 | NR1H4 (0.46) | RAF1BRAFMAPTMEN1KMT2A | |
| SCHEMBL4420074 | 0.84 | RAF1 (0.49) | RAF1BRAFRXFP1NPC1MAPK14 | |
| SCHEMBL4409369 | 0.84 | RAB9A (0.51) | RAF1BRAFMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4411700 | 0.83 | MEN1 (0.43) | RAF1BRAFMAPTMEN1KMT2A | |
| SCHEMBL4412543 | 0.81 | ALDH1A1 (0.42) | RAF1BRAFMAPTMEN1KMT2A | |
| SCHEMBL14473259 | 0.78 | GSK3A (0.41) | RAF1BRAFMAPTUSP30MAPK14 | |
| SCHEMBL4407658 | 0.78 | NPC1 (0.42) | BRAFMEN1KMT2AGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |