Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | JUN | P05412 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.57 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.55 |
| ▸ | VCP | P55072 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11401919 | 0.93 | TNFSF11 (0.55) | TSHRJUNNFKB1PTGS1NR3C1 | |
| SCHEMBL9360952 | 0.90 | TSHR (0.58) | TSHRJUNNFKB1PTGS1NR3C1 | |
| SCHEMBL10425842 | 0.81 | TSHR (0.66) | TSHRJUNNFKB1PTGS1NR3C1 | |
| SCHEMBL27090 | 0.80 | CA2 (0.54) | TSHRNR3C1ALDH1A1GAAKDM4E | |
| SCHEMBL2729632 | 0.79 | TSHR (0.64) | TSHRJUNNFKB1PTGS1NR3C1 | |
| SCHEMBL3328971 | 0.79 | TSHR (0.64) | TSHRJUNNFKB1PTGS1NR3C1 | |
| SCHEMBL18052474 | 0.79 | TSHR (0.64) | TSHRJUNNFKB1PTGS1NR3C1 | |
| SCHEMBL171836 | 0.79 | TSHR (0.64) | TSHRJUNNFKB1PTGS1NR3C1 | |
| SCHEMBL11347760 | 0.79 | TSHR (0.64) | TSHRJUNNFKB1PTGS1NR3C1 | |
| SCHEMBL28742168 | 0.79 | ACHE (0.46) | TSHRPTGS1NR3C1TNFSF11RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014144073-A2 | AUGMENTING MOIETIES FOR ANTI-INFLAMMATORY COMPOUNDS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2014-09-18 | — | — | WO | claimed |
| CN-1280578-A | Bis-quaternary ammonium derivatives as neuromuscular relaxants | NEWLAKSONT CO LTD (US) | 2001-01-17 | — | — | CN | claimed |
| US-5990124-A | ALKOXY AND/OR ACYLOXY DI- AND POLY-SUBSTITUTED ARALKYL AND ARALKENYL BIS-QUATERNARY AMMONIUM DERIVATIVES OF CYCLIC ALKANOL DIESTERS; SUCH AS BIS(N-(4-ACETOXY-3-METHOXYBENZYL) TROPANIUM-3-YL)-3,6-ENDOMETHYLENE-1,2,3,6-TETRAHYDROPHTHALATE | GYERMEK LASZLO (US) | 1999-11-23 | — | — | US | claimed |
| US-4200575-A | 7[(2-Thiazolyl)-2-(oxoimino)acetamido]cephalosporin derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-04-29 | — | — | US | claimed |
| US-20090203774-A1 | SUBSTITUTED BENZYL ESTER DERIVATIVE AND USE THEREOF | AJINOMOTO CO., INC. (JP) | 2009-08-13 | — | — | US | disclosed |
| CN-101125864-A | Heteroaromatic inhibitor for fructose-1,6-bisphosphatase | METABASIS THERAPEUTICS INC (US) | 2008-02-20 | — | — | CN | disclosed |
| CN-100349904-C | Novel heteroaromatic inhibitors of fructose-1, 6-bisphosphatase | METABASIS THERAPEUTICS INC (US) | 2007-11-21 | — | — | CN | disclosed |
| CN-1900087-A | Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase | METABASIS THERAPEUTICS INC (US) | 2007-01-24 | — | — | CN | disclosed |
| CN-1704423-A | Novel heteroaromatic inhibitors of fructose-1, 6-bisphosphatase | METABASIS THERAPEUTICS INC (US) | 2005-12-07 | — | — | CN | disclosed |
| CN-1215076-C | Novel heteroaromatic inhibitors of fructose-1, 6-bisphosphatase | METABASIS THERAPEUTICS INC (US) | 2005-08-17 | — | — | CN | disclosed |
| US-20040110665-A1 | Desleucyl glycopeptide antibiotics and methods of making same | KAHNE DANIEL (US) | 2004-06-10 | — | — | US | disclosed |
| US-6699836-B2 | Vancomycin analogs | THE TRUSTEES OF PRINCETON UNIVERSITY | 2004-03-02 | — | — | US | disclosed |
| US-4812446-A | CAPSAICINOID AND SALICYLATE | THE PROCTER & GAMBLE COMPANY (US) | 1989-03-14 | — | — | US | disclosed |
| EP-0306060-A2 | Pharmaceutical products providing enhanced analgesia | THE PROCTER & GAMBLE COMPANY (US) | 1989-03-08 | — | — | EP | disclosed |
| US-4681897-A | CAPSAICIN OR ANALOGUE WITH A NONSTEROIDAL ANALGESIC | THE PROCTER & GAMBLE COMPANY (US) | 1987-07-21 | — | — | US | disclosed |
| US-4599342-A | MIXTURE OF CAPSAICIN WITH OPIOID | THE PROCTER & GAMBLE COMPANY (US) | 1986-07-08 | — | — | US | disclosed |
| EP-0149545-A2 | Pharmaceutical products providing enhanced analgesia | THE PROCTER & GAMBLE COMPANY (US) | 1985-07-24 | — | — | EP | disclosed |
| EP-0149544-A2 | Pharmaceutical products providing enhanced analgesia | THE PROCTER & GAMBLE COMPANY (US) | 1985-07-24 | — | — | EP | disclosed |
| US-4280008-A | CHEMICAL INTERMEDIATES FOR OPTICALLY ACTIVE AMINO ACIDS | BASF AKTIENGESELLSCHAFT (DE) | 1981-07-21 | — | — | US | disclosed |
| US-4200575-A | 7[(2-Thiazolyl)-2-(oxoimino)acetamido]cephalosporin derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110665-A1 | Desleucyl glycopeptide antibiotics and methods of making same | FUT6, FUT5, ST6GAL1 | TSHR 2445/4885JUN 2419/4885NFKB1 2492/4885 |
| US-20090203774-A1 | SUBSTITUTED BENZYL ESTER DERIVATIVE AND USE THEREOF | MEP1B, EBP, MEP1A | TSHR 3982/4885JUN 3580/4885NFKB1 865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.