SCHEMBL441536

SCHEMBL441536

Nc1ncnc2c1ncn2[C@]1(C(=O)c2ccccc2)O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 2/20 0.47
ADORA3 P0DMS8 5/20 0.45
ADORA2A P29274 4/20 0.45
PI4KA P42356 2/20 0.45
PI4K2B Q8TCG2 2/20 0.45
PI4K2A Q9BTU6 2/20 0.45
PI4KB Q9UBF8 2/20 0.45
SLC28A1 O00337 2/20 0.45
DPP4 P27487 1/20 0.45
MEN1 O00255 1/20 0.45
MAP3K7 O43318 1/20 0.45
SLC28A2 O43868 1/20 0.45
GAPDH P04406 1/20 0.45
MAPK1 P28482 1/20 0.45
ADORA2B P29275 1/20 0.45
ADORA1 P30542 1/20 0.45
STAT6 P42226 1/20 0.45
KMT2A Q03164 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
DOT1L Q8TEK3 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31644935 1.00 EGFR (0.47) EGFRADORA3ADORA2API4KAPI4K2B
SCHEMBL30041710 0.96 DOT1L (0.45) EGFRADORA3ADORA2API4KAPI4K2B
SCHEMBL9501856 0.95 EGFR (0.43) EGFRADORA3ADORA2API4KAPI4K2B
SCHEMBL2205117 0.92 EGFR (0.44) EGFRADORA3ADORA2API4KAPI4K2B
SCHEMBL4916912 0.90 ADORA3 (0.48) EGFRADORA3ADORA2API4KAPI4K2B
SCHEMBL7156326 0.89 EGFR (0.42) EGFRADORA3ADORA2API4KAPI4K2B
SCHEMBL4451633 0.89 ADORA3 (0.43) EGFRADORA3ADORA2API4KAPI4K2B
SCHEMBL30406718 0.89 EGFR (0.42) EGFRADORA3ADORA2API4KAPI4K2B
SCHEMBL337874 0.89 ADORA3 (0.45) ADORA3ADORA2API4KAPI4K2BPI4K2A
Phosphoric Acid SCHEMBL16070005 0.89 ADORA3 (0.42) EGFRADORA3ADORA2API4KAPI4K2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 307 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117886868-A Preparation method of 5' -DMT nucleoside compound 天津奥瑞芙生物医药有限公司 2024-04-16 CN claimed
WO-2006038865-A1 NUCLEOTIDE DERIVATIVES FOR THE TREATMENT OF TYPE 2 DIABETES AND OTHER DISORDERS BETAGENON AB (SE) 2006-04-13 WO claimed
US-12576099-B2 Ribose-modified cap analog and use thereof BEIJING YOUCARE KECHUANG PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) 2026-03-17 US disclosed
US-20260071217-A1 ANTISENSE OLIGOMER COMPOUNDS SAREPTA THERAPEUTICS, INC. (US) 2026-03-12 US disclosed
EP-4650358-A2 RIBOSE-MODIFIED CAP ANALOG AND USE THEREOF Beijing Youcare Kechuang Pharmaceutical Technology Co., Ltd. (CN) 2025-11-19 EP disclosed
US-12474327-B2 Metabolic profiling for the diagnosis of a subset of idiopathic autism spectrum disorder patients, ADS Phenotype 1 STALICLA SA (CH) 2025-11-18 US disclosed
US-20250332189-A1 RIBOSE-MODIFIED CAP ANALOG AND USE THEREOF BEIJING YOUCARE KECHUANG PHARMACEUTICAL TECH CO LTD (CN) 2025-10-30 US disclosed
US-20250241940-A1 MODIFIED ANTISENSE OLIGOMERS FOR EXON INCLUSION IN SPINAL MUSCULAR ATROPHY JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2025-07-31 US disclosed
US-20250171779-A1 ANTISENSE OLIGOMERS AND METHODS OF USING THE SAME FOR TREATING DISEASES ASSOCIATED WITH THE ACID ALPHA-GLUCOSIDASE GENE SAREPTA THERAPEUTICS, INC. (US) 2025-05-29 US disclosed
US-20250171783-A1 ANTISENSE-INDUCED EXON2 INCLUSION IN ACID ALPHA-GLUCOSIDASE SAREPTA THERAPEUTICS, INC. 2025-05-29 US disclosed
EP-4493694-A1 MODIFIED GAPMER OLIGOMERS AND METHODS OF USE THEREOF Aligos Therapeutics, Inc. (US) 2025-01-22 EP disclosed
WO-1993003052-A1 MULTIDOMAIN DNA LIGANDS FOR PROTEIN AND NUCLEIC ACID AFFINITY CHROMATOGRAPHY AND PROCESSING OF SOLID-PHASE DNA ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 1993-02-18 WO disclosed
EP-0420872-A4 THERAPEUTIC USES OF 2',5'-OLIGOADENYLATE DERIVATIVES 1992-10-21 EP disclosed
WO-1991010671-A1 COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 1991-07-25 WO disclosed
EP-0420872-A1 THERAPEUTIC USES OF 2',5'-OLIGOADENYLATE DERIVATIVES. UNIV TEMPLE (US) 1991-04-10 EP disclosed
CN-1040321-A 2 ', 5 '-therapeutic use of oligomerization adenylic acid derivant UNIV TEMPLE (US) 1990-03-14 CN disclosed
EP-0270651-A4 NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES. CALIFORNIA INST OF TECHN (US) 1989-03-29 EP disclosed
EP-0270651-A1 NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES. CALIFORNIA INST OF TECHN (US) 1988-06-15 EP disclosed
WO-1988000201-A1 NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES CALIFORNIA INSTITUTE OF TECHNOLOGY, INC. (US) 1988-01-14 WO disclosed
EP-0121112-B1 2'-DEOXY-3-PHOSPHONYLMETHYL NUCLEOSIDES AND METHOD FOR THEIR PREPARATION Gesellschaft für Biotechnologische Forschung mbH (GBF) (DE) 1987-05-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12576099-B2 Ribose-modified cap analog and use thereof RNMT, RNGTT, NSUN2 EGFR 4803/4885ADORA3 1776/4885ADORA2A 1039/4885
US-20260071217-A1 ANTISENSE OLIGOMER COMPOUNDS DCLRE1B, OGG1, DCTD EGFR 1618/4885ADORA3 279/4885ADORA2A 362/4885
US-20250332189-A1 RIBOSE-MODIFIED CAP ANALOG AND USE THEREOF RNMT, RNGTT, CPSF1 EGFR 4565/4885ADORA3 941/4885ADORA2A 557/4885
US-20250171779-A1 ANTISENSE OLIGOMERS AND METHODS OF USING THE SAME FOR TREATING DISEASES ASSOCIATED WITH THE ACID ALPHA-GLUCOSIDASE GENE GAA, GBA3, GBA1 EGFR 4749/4885ADORA3 2466/4885ADORA2A 3135/4885
US-20250241940-A1 MODIFIED ANTISENSE OLIGOMERS FOR EXON INCLUSION IN SPINAL MUSCULAR ATROPHY SMN1; SMN2, UPF1, RBM17 EGFR 4535/4885ADORA3 3348/4885ADORA2A 2957/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.