Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.75 |
| ▸ | ESRRG | P62508 | 1/20 | 0.59 |
| ▸ | CNR2 | P34972 | 4/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27732459 | 0.98 | TSHR (0.72) | TSHRESRRGCNR2CYP19A1NR1H2 | |
| SCHEMBL10702263 | 0.93 | TSHR (0.75) | TSHRESRRGCNR2NR1H2NR1H3 | |
| SCHEMBL4407628 | 0.90 | TSHR (0.91) | TSHRESRRGCNR2NR1H2NR1H3 | |
| SCHEMBL8975208 | 0.88 | TSHR (0.55) | TSHRESRRGCNR2CYP19A1NR1H2 | |
| SCHEMBL179996 | 0.86 | TSHR (1.00) | TSHRESRRGCNR2NR1H2NR1H3 | |
| SCHEMBL20119625 | 0.85 | TSHR (0.81) | TSHRESRRGCNR2NR1H2NR1H3 | |
| SCHEMBL4400867 | 0.85 | TSHR (0.81) | TSHRESRRGCNR2NR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL3672654 | 0.84 | TSHR (0.96) | TSHRESRRGCNR2NR1H2NR1H3 | |
| Bromide SCHEMBL27967621 | 0.84 | TSHR (0.96) | TSHRESRRGCNR2NR1H2NR1H3 | |
| SCHEMBL11725374 | 0.83 | TSHR (0.78) | TSHRCNR2NR1H2NR1H3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812827-B1 | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation | SUMITOMO CHEMICAL CO (JP) | 2009-09-02 | — | — | EP | disclosed |
| US-6815548-B2 | MINTERMEDIATE FOR PHARMACEUTICALS SUCH AS PAROXETINE USEFUL AS ANTIDEPRESSANTS, REPRESENTED BY THE GENERAL FORMULA (I): | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2004-11-09 | — | — | US | disclosed |
| US-6730803-B2 | PRODUCTION METHOD OF A BETA -KETO ESTER COMPOUND OF CLAIM 1, WHICH COMPRISES CONDENSATION OF A 2-CYANO-2,2-DIMETHYLACETATE SOLUTION TO GIVE 2-CYANO-2,2- DIMETHYLACETATE OF THE FORMULA (II), AND CONDENSATION THEREOF | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2004-05-04 | — | — | US | disclosed |
| EP-1394160-A1 | Process for preparing crystalline paroxetin hydrochloride | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2004-03-03 | — | — | EP | disclosed |
| EP-1384720-A1 | Process for drying paroxetine hydrochloride | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2004-01-28 | — | — | EP | disclosed |
| EP-1384711-A1 | Optical resolution of a piperidine derivative | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2004-01-28 | — | — | EP | disclosed |
| US-6610851-B1 | 1-tert-butoxycarbonyl-4-(4-fluorophenyl)-3-((3,4-methylene dioxyphenyl)oxymethyl)piperidine; reacting 4-(4-fluorophenyl)-3-hydroxymethylpiperidine with di-tert-butyl dicarbonate to form the carbamate; 3,4-methylenedioxyphenol | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2003-08-26 | — | — | US | disclosed |
| US-20030144519-A1 | Process for preparing a piperidine derivative | SUMIKA FINE CHEMICALS CO., LTD. | 2003-07-31 | — | — | US | disclosed |
| US-20030144533-A1 | Synthetic intermediate for epothilone derivative and production method thereof | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2003-07-31 | — | — | US | disclosed |
| US-6476227-B1 | Piperidine derivative and process for preparing the same | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| US-5948914-A | PREPARING 4-(4-FLUOROPHENYL)-3-HYDROXYMETHYLPIPERIDINE BY OPTICALLY RESOLVING WITH O-CHLOROTARTRANILIC ACID; CHEMICAL INTERMEDIATE FOR DRUGS | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0812827-A1 | Piperidine derivative as intermediates for the preparation of paroxetine and process for their preparation | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 1997-12-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144519-A1 | Process for preparing a piperidine derivative | TPH1, TPH2, HTR7 | TSHR 681/4885ESRRG 2158/4885CNR2 333/4885 |
| US-20030144533-A1 | Synthetic intermediate for epothilone derivative and production method thereof | HSD11B1, HSD17B7, HSD17B1 | TSHR 2086/4885ESRRG 1147/4885CNR2 4677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.