SCHEMBL4424322

SCHEMBL4424322

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nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.60
PTGS2 P35354 2/20 0.60
BLM P54132 2/20 0.60
KDM4E B2RXH2 1/20 0.60
THRB P10828 1/20 0.60
ALOX15 P16050 1/20 0.60
NFKB1 P19838 1/20 0.60
THPO P40225 1/20 0.60
RECQL P46063 1/20 0.60
SMN1; SMN2 Q16637 1/20 0.60
PTGS1 P23219 1/20 0.55
GSTK1 Q9Y2Q3 1/20 0.55
ALDH1A1 P00352 4/20 0.50
LMNA P02545 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
MME P08473 5/20 0.43
ACE P12821 5/20 0.43
CPA1 P15085 1/20 0.43
ACE2 Q9BYF1 1/20 0.43
ECE1 P42892 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18263621 1.00 MAPT (0.60) MAPTPTGS2BLMKDM4ETHRB
SCHEMBL4632742 0.96 MAPT (0.56) MAPTPTGS2BLMKDM4ETHRB
SCHEMBL17287153 0.93 PTGS1 (0.57) MAPTPTGS2BLMKDM4ETHRB
SCHEMBL30065558 0.93 PTGS1 (0.54) MAPTPTGS2BLMKDM4ETHRB
SCHEMBL29774451 0.88 PTGS1 (0.52) MAPTPTGS2BLMKDM4ETHRB
SCHEMBL14647811 0.87 MAPT (0.54) MAPTPTGS2BLMKDM4ETHRB
SCHEMBL236405 0.85 PTGS1 (0.67) MAPTPTGS2BLMKDM4ETHRB
SCHEMBL20787749 0.85 PTGS1 (0.67) MAPTPTGS2BLMKDM4ETHRB
SCHEMBL19579377 0.85 PTGS1 (0.58) MAPTPTGS2BLMKDM4ETHRB
SCHEMBL18862364 0.84 MAPT (0.53) MAPTPTGS2BLMKDM4ETHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260124166-A1 COMPOSITIONS AND METHODS USING GLYCINE TO REDUCE BIOLOGICAL AGE OF AN ADULT ANIMAL Société des Produits Nestlé S.A. (CH) 2026-05-07 US claimed
EP-4615434-A1 COMPOSITIONS AND METHODS USING GLYCINE TO REDUCE BIOLOGICAL AGE OF AN ADULT ANIMAL Société des Produits Nestlé S.A. (CH) 2025-09-17 EP claimed
WO-2024099883-A1 COMPOSITIONS AND METHODS USING GLYCINE TO REDUCE BIOLOGICAL AGE OF AN ADULT ANIMAL Société des Produits Nestlé S.A. (CH) 2024-05-16 WO claimed
US-11730711-B2 Benefits of supplementation with n-acetylcysteine and glycine to improve glutathione levels BAYLOR COLLEGE OF MEDICINE (US) 2023-08-22 US claimed
WO-2021232041-A1 N-ACETYLCYSTEINE AND GLYCINE FOR TREATMENT OF COVID-19 AND POST COVID-19 SYMPTOMS BAYLOR COLLEGE OF MEDICINE (US) 2021-11-18 WO claimed
US-20210244696-A1 BENEFITS OF SUPPLEMENTATION WITH N-ACETYLCYSTEINE AND GLYCINE TO IMPROVE GLUTATHIONE LEVELS BAYLOR COLLEGE OF MEDICINE 2021-08-12 US claimed
US-10952982-B2 Benefits of supplementation with N-acetylcysteine and glycine to improve glutathione levels SOCIETE DES PRODUITS NESTLE S.A. (CH) 2021-03-23 US claimed
US-20180161297-A1 BENEFITS OF SUPPLEMENTATION WITH N-ACETYLCYSTEINE AND GLYCINE TO IMPROVE GLUTATHIONE LEVELS Société des Produits Nestlé S.A. (CH) 2018-06-14 US claimed
EP-3302459-A1 BENEFITS OF SUPPLEMENTATION WITH N-ACETYLCYSTEINE AND GLYCINE TO IMPROVE GLUTATHIONE LEVELS Baylor College of Medicine (US) 2018-04-11 EP claimed
WO-2016191468-A1 BENEFITS OF SUPPLEMENTATION WITH N-ACETYLCYSTEINE AND GLYCINE TO IMPROVE GLUTATHIONE LEVELS BAYLOR COLLEGE OF MEDICINE (US) 2016-12-01 WO claimed
US-20260124166-A1 COMPOSITIONS AND METHODS USING GLYCINE TO REDUCE BIOLOGICAL AGE OF AN ADULT ANIMAL Société des Produits Nestlé S.A. (CH) 2026-05-07 US disclosed
US-12496285-B2 Compositions and methods using at least one glycine or derivative thereof, at least one N-acetylcysteine or derivative thereof, and at least one nicotinamide riboside or NAD+ precursor SOCIETE DES PRODUITS NESTLE S.A. (CH) 2025-12-16 US disclosed
EP-4615434-A1 COMPOSITIONS AND METHODS USING GLYCINE TO REDUCE BIOLOGICAL AGE OF AN ADULT ANIMAL Société des Produits Nestlé S.A. (CH) 2025-09-17 EP disclosed
US-12186292-B2 Benefits of supplementation with n-acetylcysteine and glycine to improve glutathione levels SOCIETE DES PRODUITS NESTLE S.A. (CH) 2025-01-07 US disclosed
US-20240410864-A1 METHOD FOR DETECTING AND/OR QUANTIFYING MOOD DISORDER AND/OR IMPROVEMENTS OF THE MOOD DISORDER STATUS USING CONJUGATED BILE ACIDS AS BIOMARKER AND IMPROVED METHODS AND COMPOSITIONS THEREOF NESTLE SA (CH) 2024-12-12 US disclosed
US-20100048587-A1 CYSTEINE AND CYSTINE BIOISOSTERES TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS MARQUETTE UNIVERSITY (US) 2010-02-25 US disclosed
US-20090105150-A1 Angiotensin derivatives PROTHERICS MEDICINES DEVELOPMENT LIMITED (GB) 2009-04-23 US disclosed
US-7378489-B1 Angiotensin derivatives PROTHERICS MEDICINES DEVELOPMENT LIMITED (GB) 2008-05-27 US disclosed
EP-0536231-A1 A PROCESS FOR THE PREPARATION OF GLUTATHIONE S-ACYL DERIVATIVES, COMPOUNDS OBTAINED FROM SAID PROCESS AND AN INTERMEDIATE USEFUL FOR THE PREPARATION THEREOF. BOEHRINGER MANNHEIM ITALIA (IT) 1993-04-14 EP disclosed
WO-1992000320-A1 A PROCESS FOR THE PREPARATION OF GLUTATHIONE S-ACYL DERIVATIVES, COMPOUNDS OBTAINED FROM SAID PROCESS AND AN INTERMEDIATE USEFUL FOR THE PREPARATION THEREOF BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1992-01-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260124166-A1 COMPOSITIONS AND METHODS USING GLYCINE TO REDUCE BIOLOGICAL AGE OF AN ADULT ANIMAL GLS, AGER, LRRK2 MAPT 1402/4885PTGS2 108/4885BLM 4473/4885
US-20090105150-A1 Angiotensin derivatives AGTR1, AGTR2, AGT MAPT 2409/4885PTGS2 779/4885BLM 2677/4885
US-20100048587-A1 CYSTEINE AND CYSTINE BIOISOSTERES TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS CTH, CBS, SLC7A11 MAPT 2979/4885PTGS2 2922/4885BLM 4380/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.