Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | NEK2 | P51955 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL125219 | 0.85 | ALDH1A1 (0.41) | MAPTWDR5TDP1ALDH1A1CYP2A6 | |
| Hydrochloric Acid SCHEMBL30032917 | 0.85 | ALDH1A1 (0.41) | MAPTWDR5TDP1ALDH1A1CYP2A6 | |
| SCHEMBL10323632 | 0.85 | ALDH1A1 (0.44) | MAPTWDR5TDP1ALDH1A1CYP2A6 | |
| SCHEMBL29496111 | 0.85 | ALDH1A1 (0.44) | MAPTWDR5TDP1ALDH1A1CYP2A6 | |
| SCHEMBL29350037 | 0.85 | ALDH1A1 (0.44) | MAPTWDR5TDP1ALDH1A1CYP2A6 | |
| SCHEMBL146878 | 0.85 | ALDH1A1 (0.44) | MAPTWDR5TDP1ALDH1A1CYP2A6 | |
| SCHEMBL5107 | 0.85 | ALDH1A1 (0.44) | MAPTWDR5TDP1ALDH1A1CYP2A6 | |
| SCHEMBL15271042 | 0.84 | ALDH1A1 (0.42) | MAPTWDR5TDP1ALDH1A1CYP2A6 | |
| SCHEMBL5149451 | 0.84 | ALDH1A1 (0.42) | MAPTWDR5TDP1ALDH1A1CYP2A6 | |
| SCHEMBL3416712 | 0.84 | ALDH1A1 (0.42) | MAPTWDR5TDP1ALDH1A1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110872268-B | Isocoumarin derivative and preparation method and medicinal application thereof | 复旦大学 | 2023-07-25 | — | — | CN | disclosed |
| US-20220081413-A1 | SYNTHESIS OF QUINAZOLINE COMPOUNDS | GENENTECH, INC. (US) | 2022-03-17 | — | — | US | disclosed |
| US-11198701-B2 | Biaryl ligands, methods of making biarlyl ligands, and methods of use thereof | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2021-12-14 | — | — | US | disclosed |
| US-20200223878-A1 | BIARYL LIGANDS, METHODS OF MAKING BIARLYL LIGANDS, AND METHODS OF USE THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2020-07-16 | — | — | US | disclosed |
| US-9994599-B2 | Biaryl ligands | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| US-9994599-B2 | Biaryl ligands | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| US-20170173572-A1 | CHIRAL LIGAND-BASED METAL-ORGANIC FRAMEWORKS FOR BROAD-SCOPE ASYMMETRIC CATALYSIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-06-22 | — | — | US | disclosed |
| EP-2583958-B1 | Ligands for metals and improved metal-catalyzed processes based thereon | MASSACHUSETTS INST TECHNOLOGY (US) | 2016-08-10 | — | — | EP | disclosed |
| EP-2583958-B1 | Ligands for metals and improved metal-catalyzed processes based thereon | MASSACHUSETTS INST TECHNOLOGY (US) | 2016-08-10 | — | — | EP | disclosed |
| US-20160222041-A1 | BIARYL LIGANDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2016-08-04 | — | — | US | disclosed |
| US-7223879-B2 | Ligands for metals and improved metal-catalyzed processes based thereon | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-05-29 | — | — | US | disclosed |
| EP-1354887-B1 | Ligands for metals and improved metal-catalyzed processes based thereon | MASSACHUSETTS INST TECHNOLOGY (US) | 2007-04-25 | — | — | EP | disclosed |
| US-7026498-B2 | Coordination catalyst containing ligand | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2006-04-11 | — | — | US | disclosed |
| US-20060069257-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | NATIONAL SCIENCE FOUNDATION | 2006-03-30 | — | — | US | disclosed |
| EP-1097158-B1 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INST TECHNOLOGY (US) | 2006-01-25 | — | — | EP | disclosed |
| US-6946560-B2 | Ligands for metals and improved metal-catalyzed processes based thereon | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2005-09-20 | — | — | US | disclosed |
| US-20040171833-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | NATIONAL SCIENCE FOUNDATION | 2004-09-02 | — | — | US | disclosed |
| US-20040010149-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | NATIONAL SCIENCE FOUNDATION | 2004-01-15 | — | — | US | disclosed |
| US-6395916-B1 | AMINE, PHOSPHINE LIGANDS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2002-05-28 | — | — | US | disclosed |
| US-6307087-B1 | USE OF CATALYSTS COMPRISING THESE LIGANDS IN TRANSITION METAL-CATALYZED CARBON-HETEROATOM AND CARBON-CARBON BOND-FORMING REACTIONS. | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2001-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220081413-A1 | SYNTHESIS OF QUINAZOLINE COMPOUNDS | COQ8A, SQSTM1, QARS1 | MAPT 650/4885CHEK1 244/4885NEK2 149/4885 |
| US-20170173572-A1 | CHIRAL LIGAND-BASED METAL-ORGANIC FRAMEWORKS FOR BROAD-SCOPE ASYMMETRIC CATALYSIS | POF1B, FGFR1, COASY | MAPT 4198/4885CHEK1 800/4885NEK2 1449/4885 |
| US-20040010149-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | THEM6, SOD1, SLC30A6 | MAPT 2210/4885CHEK1 2343/4885NEK2 2471/4885 |
| US-20060069257-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | THEM6, PICALM, SLC30A6 | MAPT 2998/4885CHEK1 1652/4885NEK2 2724/4885 |
| US-11198701-B2 | Biaryl ligands, methods of making biarlyl ligands, and methods of use thereof | BID, EBPL, BPHL | MAPT 4465/4885CHEK1 1313/4885NEK2 1879/4885 |
| US-20200223878-A1 | BIARYL LIGANDS, METHODS OF MAKING BIARLYL LIGANDS, AND METHODS OF USE THEREOF | BID, EBPL, BPHL | MAPT 4465/4885CHEK1 1313/4885NEK2 1879/4885 |
| US-20040171833-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | THEM6, SLC30A6, SOD1 | MAPT 2351/4885CHEK1 2473/4885NEK2 2599/4885 |
| US-20160222041-A1 | BIARYL LIGANDS | BID, BLVRB, ABCG2 | MAPT 4010/4885CHEK1 1309/4885NEK2 1899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.