SCHEMBL442701

SCHEMBL442701

CC(=CCCC[Si](C)(C)O[Si](C)(C)C)C(=O)O

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TBXAS1 P24557 1/20 0.33
CD81 P60033 1/20 0.32
PPARG P37231 1/20 0.31
EP300 Q09472 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17911297 0.93 TBXAS1 (0.35) TBXAS1CD81PPARGEP300
SCHEMBL3768512 0.92 TBXAS1 (0.32) TBXAS1CD81
SCHEMBL400292 0.86 TBXAS1 (0.33) TBXAS1CD81PPARGEP300
SCHEMBL809437 0.86 TBXAS1 (0.33) TBXAS1CD81PPARGEP300
SCHEMBL1581278 0.86 TBXAS1 (0.33) TBXAS1CD81PPARGEP300
SCHEMBL30912180 0.85 TSHR (0.39)
SCHEMBL25347894 0.84 TBXAS1 (0.34) TBXAS1CD81PPARGEP300
SCHEMBL20958100 0.83 EP300 (0.37) TBXAS1EP300
SCHEMBL20958102 0.83 EP300 (0.37) TBXAS1EP300
SCHEMBL8466019 0.82 TBXAS1 (0.32) TBXAS1CD81

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3756874-A2 PINHOLE CONTACT LENS FORMING JIG Seed Co., Ltd. (JP) 2020-12-30 EP disclosed
US-9238715-B2 Polymerizable composition for ophthalmic and medical use and antimicrobial composition obtained by polymerizing the polymerizable composition NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2016-01-19 US disclosed
EP-2650021-B1 MEDICAL DEVICE FOR CONTROLLED RELEASE OF DRUG SEED CO LTD (JP) 2015-12-09 EP disclosed
US-9056880-B2 Process for producing hydrolysis-resistant silicone compounds JOHNSON & JOHNSON VISION CARE, INC. (US) 2015-06-16 US disclosed
US-9034942-B2 Polymer material, ophthalmic lens and contact lens MENICON CO., LTD. (JP) 2015-05-19 US disclosed
US-8921449-B2 Hydrolysis-resistant silicone compounds JOHNSON & JOHNSON VISION CARE INC. (US) 2014-12-30 US disclosed
US-20140163133-A1 POLYMERIZABLE COMPOSITION FOR OPHTHALMIC AND MEDICAL USE AND ANTIMICROBIAL COMPOSITION OBTAINED BY POLYMERIZING THE POLYMERIZABLE COMPOSITION MENICON CO., LTD (JP) 2014-06-12 US disclosed
US-20140128564-A1 PROCESS FOR PRODUCING HYDROLYSIS-RESISTANT SILICONE COMPOUNDS FUJISAWA KAZUHIKO (JP) 2014-05-08 US disclosed
US-8637589-B2 Silicone prepolymer solutions JOHNSON & JOHNSON VISION CARE, INC. (US) 2014-01-28 US disclosed
EP-2388281-B1 SILICONE MONOMER NOF CORP (JP) 2013-11-06 EP disclosed
US-20090171026-A1 SILICONE PREPOLYMER SOLUTIONS JOHNSON & JOHNSON VISION CARE, INC. 2009-07-02 US disclosed
US-20090005528-A1 SOLUBLE SILICONE PREPOLYMERS JOHNSON & JOHNSON VISION CARE, INC. 2009-01-01 US disclosed
US-20080094570-A1 Highly Oxygen-Permeable Hydrated Ocular Lens SEED CO., LTD. (JP) 2008-04-24 US disclosed
US-20080081850-A1 Such as reaction of butyldimethylsilanol with 3-trichlorosilylpropyl methacrylate to produce 3-[tris(butyldimethylsiloxy)silyl]propyl methacrylate; steric hindrance, purity; copolymers with acrylate endcapped polysiloxane and acrylic monomers; contact and intraocular lenses, artificial cornea JOHNSON & JOHNSON VISION CARE, INC. 2008-04-03 US disclosed
US-7317117-B2 Siloxanyl-containing monomers JOHNSON & JOHNSON VISION CARE, INC. (US) 2008-01-08 US disclosed
US-20080004401-A1 SILOXANYL MATERIALS FOR MOLDED PLASTICS JOHNSON & JOHNSON VISION CARE, INC. 2008-01-03 US disclosed
US-20080004383-A1 ACRYLOYL MATERIALS FOR MOLDED PLASTICS TORAY INDUSTRIES, INC. (JP) 2008-01-03 US disclosed
EP-1832913-A1 COMPOSITE CONTACT LENS AND PRODUCTION METHOD FOR LENS MATERIAL HOYA CORPORATION (JP) 2007-09-12 EP disclosed
EP-1806614-A1 HIGHLY OXYGEN-PERMEABLE HYDRATED OCULAR LENS Seed Co., Ltd. (JP) 2007-07-11 EP disclosed
US-20070100018-A1 Functionalized dyes and use thereof in ophthalmic lens material OPHTEC B.V. (NL) 2007-05-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140128564-A1 PROCESS FOR PRODUCING HYDROLYSIS-RESISTANT SILICONE COMPOUNDS LSS, PIGS, STS TBXAS1 4230/4885CD81 4063/4885PPARG 4290/4885
US-20090005528-A1 SOLUBLE SILICONE PREPOLYMERS NOS3, NOS2, PCNA TBXAS1 617/4885CD81 3667/4885PPARG 2296/4885
US-20080004383-A1 ACRYLOYL MATERIALS FOR MOLDED PLASTICS ACR, HAAO, PORCN TBXAS1 1033/4885CD81 3775/4885PPARG 3268/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.