SCHEMBL4427303

SCHEMBL4427303

COc1ccc(Nc2ccc(C)cc2)cc1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.81
MAPT P10636 4/20 0.81
NPC1 O15118 3/20 0.81
GAA P10253 3/20 0.81
KDM4E B2RXH2 1/20 0.81
THRB P10828 1/20 0.81
MAPK1 P28482 1/20 0.81
RECQL P46063 1/20 0.81
NPSR1 Q6W5P4 1/20 0.81
TDP1 Q9NUW8 1/20 0.81
L3MBTL1 Q9Y468 1/20 0.81
ACHE P22303 1/20 0.71
NR4A1 P22736 1/20 0.65
ALDH1A1 P00352 3/20 0.61
HPGD P15428 2/20 0.61
SMN1; SMN2 Q16637 1/20 0.61
HTT P42858 1/20 0.57
GSK3B P49841 1/20 0.56
RELA Q04206 1/20 0.56
PTGS2 P35354 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10025013 0.94 RAB9A (0.71) RAB9AMAPTNPC1GAAKDM4E
SCHEMBL1459772 0.90 MAPT (1.00) RAB9AMAPTNPC1GAAKDM4E
SCHEMBL39057 0.90 MAPT (1.00) RAB9AMAPTNPC1GAAKDM4E
SCHEMBL8507799 0.88 RELA (0.78) RAB9AMAPTNPC1GAAKDM4E
SCHEMBL8507802 0.88 RELA (0.78) RAB9AMAPTNPC1GAAKDM4E
SCHEMBL31140067 0.88 RAB9A (0.63) RAB9AMAPTNPC1GAAKDM4E
SCHEMBL4250250 0.87 MAPT (0.61) RAB9AMAPTNPC1GAAKDM4E
SCHEMBL3967781 0.86 ACHE (0.71) RAB9AMAPTNPC1GAAKDM4E
SCHEMBL4544853 0.86 MAPT (0.71) RAB9AMAPTNPC1GAAKDM4E
SCHEMBL13983094 0.85 MAPT (0.71) RAB9AMAPTNPC1GAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 120 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116813938-A Conjugated small molecule modified hydrogel and preparation method thereof 金陵科技学院 2023-09-29 CN claimed
EP-4692071-A1 PHOTOCHROMIC COMPOUND, NAPHTHOL DERIVATIVE, CURABLE COMPOSITION, OPTICAL ARTICLE, LENS, AND EYEGLASS TOKUYAMA CORPORATION (JP) 2026-02-11 EP disclosed
CN-119751302-A N-aryl croconic acid cyanine compound and preparation method and application thereof 西南医科大学 2025-04-04 CN disclosed
WO-2024202086-A1 PHOTOCHROMIC COMPOUND, NAPHTHOL DERIVATIVE, CURABLE COMPOSITION, OPTICAL ARTICLE, LENS, AND EYEGLASS 株式会社トクヤマ 2024-10-03 WO disclosed
CN-118085286-A Polyarylether electrochromic polymer and preparation method and application thereof 吉林大学 2024-05-28 CN disclosed
WO-2023217917-A1 FUNCTIONNALISED COPPER ELECTROCHEMICAL CATALYSTS FOR CONVERSION OF CO2 TO SMALL MOLECULES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2023-11-16 WO disclosed
EP-4276224-A1 FUNCTIONNALISED COPPER ELECTROCHEMICAL CATALYSTS FOR CONVERSION OF CO2 TO SMALL MOLECULES Centre national de la recherche scientifique (FR) 2023-11-15 EP disclosed
US-20230312874-A1 COMPOUND, RUBBER MIXTURE CONTAINING THE COMPOUND, VEHICLE TIRE WHICH HAS AT LEAST ONE COMPONENT COMPRISING THE RUBBER MIXTURE, METHOD FOR PRODUCING THE COMPOUND, AND USE OF THE COMPOUND AS AN AGING PROTECTION AGENT AND/OR ANTIOXIDANT AGENT AND/OR ANTIOZONANT AND/OR DYE CONTINENTAL REIFEN DEUTSCHLAND GMBH (DE) 2023-10-05 US disclosed
CN-116813938-A Conjugated small molecule modified hydrogel and preparation method thereof 金陵科技学院 2023-09-29 CN disclosed
CN-116640085-A Method for synthesizing carbazole derivative 陕西师范大学 2023-08-25 CN disclosed
US-20040010149-A1 Ligands for metals and improved metal-catalyzed processes based thereon NATIONAL SCIENCE FOUNDATION 2004-01-15 US disclosed
EP-1167372-B1 2,2-(Diaryl)vinylphosphine compound, palladium catalyst thereof, and process for producing arylamine, diaryl, or arylalkyne with the catalyst TAKASAGO PERFUMERY CO LTD (JP) 2003-12-10 EP disclosed
EP-1354887-A1 Ligands for metals and improved metal-catalyzed processes based thereon Massachusetts Insitute of Technology (US) 2003-10-22 EP disclosed
US-20020156295-A1 Ligands for metals and improved metal-catalyzed processes based thereon NATIONAL SCIENCE FOUNDATION 2002-10-24 US disclosed
US-6455720-B1 AS CATALYSTS TAKASAGO INTERNATIONAL CORPORATION (JP) 2002-09-24 US disclosed
US-6395916-B1 AMINE, PHOSPHINE LIGANDS MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2002-05-28 US disclosed
US-20020058837-A1 2,2 (Diarlyl) Vinylphosphine compound, palladium catalyst thereof, and process for producing arylamine, diaryl, or arylalkyne with the catalyst TAKASAGO INTERNATIONAL CORPORATION (JP) 2002-05-16 US disclosed
EP-1167372-A1 2,2-(Diaryl)vinylphosphine compound, palladium catalyst thereof, and process for producing arylamine, diaryl, or arylalkyne with the catalyst Takasago International Corporation (JP) 2002-01-02 EP disclosed
US-6307087-B1 USE OF CATALYSTS COMPRISING THESE LIGANDS IN TRANSITION METAL-CATALYZED CARBON-HETEROATOM AND CARBON-CARBON BOND-FORMING REACTIONS. MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2001-10-23 US disclosed
EP-0324344-A1 Fluoran derivatives BASF Aktiengesellschaft (DE) 1989-07-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020058837-A1 2,2 (Diarlyl) Vinylphosphine compound, palladium catalyst thereof, and process for producing arylamine, diaryl, or arylalkyne with the catalyst DDT, PDCD11, PLD2 RAB9A 219/4885MAPT 4856/4885NPC1 4752/4885
US-20040010149-A1 Ligands for metals and improved metal-catalyzed processes based thereon THEM6, SOD1, SLC30A6 RAB9A 3557/4885MAPT 2210/4885NPC1 3056/4885
US-20020156295-A1 Ligands for metals and improved metal-catalyzed processes based thereon THEM6, SOD1, SLC30A6 RAB9A 3557/4885MAPT 2210/4885NPC1 3056/4885
US-20230312874-A1 COMPOUND, RUBBER MIXTURE CONTAINING THE COMPOUND, VEHICLE TIRE WHICH HAS AT LEAST ONE COMPONENT COMPRISING THE RUBBER MIXTURE, METHOD FOR PRODUCING THE COMPOUND, AND USE OF THE COMPOUND AS AN AGING PROTECTION AGENT AND/OR ANTIOXIDANT AGENT AND/OR ANTIOZONANT AND/OR DYE POT1, RIF1, TERT RAB9A 357/4885MAPT 237/4885NPC1 509/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.