Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 4/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ACP3 | P15309 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441849 | 0.85 | CTSA (0.38) | CES2CES1PDE2AACP3TRPV1 | |
| SCHEMBL4433204 | 0.84 | P2RX7 (0.39) | HSD11B1 | |
| SCHEMBL28857385 | 0.84 | RAB9A (0.43) | HSD11B1GRM5JAK2 | |
| SCHEMBL2304585 | 0.76 | ACP3 (0.56) | HSD11B1CES2CES1ACP3 | |
| SCHEMBL4441781 | 0.74 | MEN1 (0.41) | CES2CES1PDE2ASMN1; SMN2 | |
| SCHEMBL4438527 | 0.74 | CES2 (0.50) | CES2CES1SMN1; SMN2ACP3 | |
| SCHEMBL4432946 | 0.73 | FFAR1 (0.42) | CES2CES1PDE2ASMN1; SMN2ACP3 | |
| SCHEMBL4436009 | 0.72 | MEN1 (0.43) | HSD11B1CES2CES1PDE2AACP3 | |
| SCHEMBL4433211 | 0.72 | LMNA (0.41) | CES2CES1PDE2ASMN1; SMN2 | |
| SCHEMBL4432461 | 0.71 | AHR (0.39) | HSD11B1CES2CES1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |