Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPD | P32754 | 4/20 | 0.41 |
| ▸ | YEATS4 | O95619 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.41 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.41 |
| ▸ | YEATS2 | Q9ULM3 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.37 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14008573 | 0.93 | HPD (0.46) | HPDYEATS4KCNH2MLLT3MLLT1 | |
| Trifluoroacetic Acid SCHEMBL4440079 | 0.83 | YEATS4 (0.59) | YEATS4KCNH2MLLT3MLLT1YEATS2 | |
| SCHEMBL4446744 | 0.82 | DRD2 (0.43) | HPDYEATS4KCNH2MLLT3MLLT1 | |
| Trifluoroacetic Acid SCHEMBL6249083 | 0.79 | CTSS (0.45) | HPDOPRM1HSD11B1 | |
| SCHEMBL4440180 | 0.78 | GPR119 (0.52) | YEATS4KCNH2MLLT3MLLT1YEATS2 | |
| SCHEMBL14008572 | 0.74 | YEATS4 (0.66) | YEATS4KCNH2MLLT3MLLT1YEATS2 | |
| SCHEMBL5836092 | 0.72 | HPD (0.50) | HPDPIK3CADRD2SLC6A4HSD11B1 | |
| SCHEMBL4437942 | 0.72 | YEATS4 (0.47) | YEATS4KCNH2MLLT3MLLT1YEATS2 | |
| Trifluoroacetic Acid SCHEMBL4434600 | 0.71 | USP2 (0.56) | YEATS4KCNH2MLLT3MLLT1YEATS2 | |
| Hydrochloric Acid SCHEMBL5006590 | 0.71 | YEATS4 (0.46) | YEATS4KCNH2MLLT3MLLT1YEATS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | disclosed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | SPTLC1, SPTLC2, CPT1A | HPD 2458/4885YEATS4 1467/4885KCNH2 4650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.