SCHEMBL444701

SCHEMBL444701

CC(=CCCc1ccc(Cc2ccccc2)cc1)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.51
GRIK1 P39086 1/20 0.48
ALDH1A1 P00352 3/20 0.46
TBXAS1 P24557 1/20 0.46
CYP2C9 P11712 1/20 0.44
PLA2G10 O15496 1/20 0.43
PLA2G2A P14555 1/20 0.43
GPR52 Q9Y2T5 6/20 0.42
AKR1C3 P42330 1/20 0.42
FFAR1 O14842 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
HPGD P15428 1/20 0.41
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1920796 1.00 LMNA (0.51) LMNAGRIK1ALDH1A1TBXAS1CYP2C9
SCHEMBL197321 0.93 GRIK1 (0.53) GRIK1ALDH1A1CYP2C9GPR52AKR1C3
SCHEMBL197322 0.93 GRIK1 (0.53) GRIK1ALDH1A1CYP2C9GPR52AKR1C3
SCHEMBL1920266 0.87 FFAR1 (0.51) LMNAGRIK1GPR52FFAR1SMN1; SMN2
SCHEMBL1920269 0.87 FFAR1 (0.51) LMNAGRIK1GPR52FFAR1SMN1; SMN2
SCHEMBL11892322 0.84 TRPV1 (0.53) LMNAGRIK1ALDH1A1CYP2C9GPR52
SCHEMBL970817 0.83 KDM4E (0.47) LMNAGRIK1ALDH1A1TBXAS1
SCHEMBL1919934 0.83 GPR52 (0.50) GRIK1GPR52FFAR1
SCHEMBL440430 0.83 THRB (0.46) GRIK1ALDH1A1NPC1RAB9AHPGD
SCHEMBL1574137 0.83 HDAC3 (0.48) GRIK1ALDH1A1TBXAS1CYP2C9AKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4121802-B1 HIGH REFRACTIVE INDEX SILOXANE INSERT MATERIALS FOR EMBEDDED CONTACT LENSES ALCON INC (CH) 2024-07-17 EP claimed
EP-3728339-B1 COMPOSITION FOR OPHTHALMOLOGICAL PRODUCTS AMO Ireland (IE) 2022-07-06 EP claimed
EP-2303331-B1 OPHTHALMIC DEVICE HAVING THERAPEUTIC AGENT DELIVERY CAPABILITY AND METHOD OF FORMING SAME ALCON INC (CH) 2022-01-26 EP claimed
EP-3200840-B1 LOW-WATER CONTENT ACRYLATE-ACRYLAMIDE COPOLYMERS FOR OPHTHALMIC DEVICES ALCON INC (CH) 2021-11-17 EP claimed
US-10756139-B2 Organic light emitting display SAMSUNG SDI CO., LTD. (KR) 2020-08-25 US claimed
US-10727443-B2 Organic light emitting display SAMSUNG SDI CO., LTD. (KR) 2020-07-28 US claimed
US-10570220-B2 Composition for display sealing material, organic protection layer comprising same, and display device comprising same SAMSUNG SDI CO., LTD. (KR) 2020-02-25 US claimed
EP-3200839-B1 HYDROPHOBIC ACRYLATE-ACRYLAMIDE COPOLYMERS FOR OPHTHALMIC DEVICES NOVARTIS AG (CH) 2019-09-04 EP claimed
US-10316112-B2 Composition for display sealing material, organic protection layer comprising same, and display device comprising same SAMSUNG SDI CO., LTD. (KR) 2019-06-11 US claimed
EP-3223870-B1 WET-PACK INTRAOCULAR LENS MATERIALS WITH HIGH REFRACTIVE INDEX NOVARTIS AG (CH) 2018-09-26 EP claimed
US-20110281995-A1 Polycarbonate Resin Composition and Molded Product Using the Same CHEIL INDUSTRIES INC. (KR) 2011-11-17 US claimed
EP-2341102-A1 Thermoplastic resin composition revealing improved impact strength and melt flow property Cheil Industries Inc. (KR) 2011-07-06 EP claimed
US-20110160377-A1 Thermoplastic Resin Composition Having Improved Impact Strength and Melt Flow Properties CHEIL INDUSTRIES INC. (KR) 2011-06-30 US claimed
EP-2225325-B1 HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS ALCON INC (CH) 2011-06-01 EP claimed
US-20100160559-A1 Polylactic Acid/Polycarbonate Resin Composition and Molded Product Made Using the Same CHEIL INDUSTRIES INC. (KR) 2010-06-24 US claimed
EP-2199342-A2 Polylactic acid/polycarbonate resin composition and molded product made using the same Cheil Industries Inc. (KR) 2010-06-23 EP claimed
EP-1080382-B1 HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS ALCON INC (CH) 2009-07-08 EP claimed
EP-1664855-B1 PROCESS FOR MANUFACTURING INTRAOCULAR LENSES WITH BLUE LIGHT ABSORPTION CHARACTERISTICS BAUSCH & LOMB (US) 2009-03-11 EP claimed
EP-1177227-B1 WATER PLASTICIZED HIGH REFRACTIVE INDEX POLYMER FOR OPHTHALMIC APPLICATIONS SURGIDEV CORP (US) 2003-10-01 EP claimed
EP-0914169-B1 MATERIALS FOR USE IN GLAUCOMA FILTRATION DEVICES ALCON LAB INC (US) 2003-07-30 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10316112-B2 Composition for display sealing material, organic protection layer comprising same, and display device comprising same ICAM1, CD40LG, VCAM1 LMNA 1762/4885GRIK1 1895/4885ALDH1A1 909/4885
US-10570220-B2 Composition for display sealing material, organic protection layer comprising same, and display device comprising same TRPA1, ALKBH1, AHCYL1 LMNA 1819/4885GRIK1 2998/4885ALDH1A1 126/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.