Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.39 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRE | P78334 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29551348 | 1.00 | NAPRT (0.50) | NAPRTCYP1A2KDM4EKEAP1GABRP | |
| Hydrochloric Acid SCHEMBL2211447 | 0.98 | NAPRT (0.48) | NAPRTCYP1A2KDM4EKEAP1GABRP | |
| SCHEMBL7537222 | 0.84 | CYP1A2 (0.46) | NAPRTCYP1A2KDM4EKEAP1GABRP | |
| SCHEMBL31253326 | 0.84 | CYP1A2 (0.46) | NAPRTCYP1A2KDM4EKEAP1GABRP | |
| SCHEMBL4775026 | 0.83 | CES2 (0.34) | NAPRTCYP1A2POLB | |
| SCHEMBL30506330 | 0.80 | SMN1; SMN2 (0.40) | NAPRTCYP1A2KDM4EALDH1A1ALOX15 | |
| SCHEMBL30934037 | 0.80 | ALDH1A1 (0.43) | NAPRTKEAP1NFE2L2ALDH1A1ALOX15 | |
| SCHEMBL30641935 | 0.80 | DGAT1 (0.42) | KDM4EALDH1A1TDP1TSHR | |
| SCHEMBL447058 | 0.80 | ALDH1A1 (0.43) | NAPRTKEAP1NFE2L2ALDH1A1ALOX15 | |
| SCHEMBL8666506 | 0.80 | KDM4E (0.47) | NAPRTCYP1A2KDM4EKEAP1GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 369 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12540129-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2026-02-03 | — | — | US | disclosed |
| EP-4658074-A1 | FUNGICIDAL COMPOSITIONS | Syngenta Crop Protection AG (CH) | 2025-12-10 | — | — | EP | disclosed |
| EP-4655284-A1 | MICROBIOCIDAL PYRAZOLE DERIVATIVES | Syngenta Crop Protection AG (CH) | 2025-12-03 | — | — | EP | disclosed |
| US-20250340569-A1 | INHIBITORS OF KIF18A AND USES THEREOF | INSILICO MEDICINE IP LTD (CN) | 2025-11-06 | — | — | US | disclosed |
| US-12441705-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2025-10-14 | — | — | US | disclosed |
| US-12441736-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2025-10-14 | — | — | US | disclosed |
| EP-4626232-A1 | FUNGICIDAL COMPOSITIONS | Syngenta Crop Protection AG (CH) | 2025-10-08 | — | — | EP | disclosed |
| EP-4619396-A1 | MICROBIOCIDAL TETRAHYDROISOQUINOLINE DERIVATIVES | Syngenta Crop Protection AG (CH) | 2025-09-24 | — | — | EP | disclosed |
| US-20250230155-A1 | 7,8-DIHYDRO-5H-1,6-NAPHTHYRIDINE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | VANDERBILT UNIVERSITY | 2025-07-17 | — | — | US | disclosed |
| WO-2025109540-A1 | MACROCYCLIC COMPOUNDS AS KIF18A INHIBITORS | AURIGENE ONCOLOGY LIMITED (IN) | 2025-05-30 | — | — | WO | disclosed |
| WO-1995019774-A1 | BICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1995-07-27 | — | — | WO | disclosed |
| US-5393733-A | Herbicidal pyridinesulfonylureas | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1995-02-28 | — | — | US | disclosed |
| US-5209770-A | Containing pyrimidine ring | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-05-11 | — | — | US | disclosed |
| US-5102444-A | Herbicidal pyridinesulfonylureas | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-04-07 | — | — | US | disclosed |
| EP-0334896-A1 | HERBICIDAL PYRIDINESULFONYLUREAS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-10-04 | — | — | EP | disclosed |
| WO-1989001937-A1 | HERBICIDAL PYRIDINESULFONYLUREAS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-03-09 | — | — | WO | disclosed |
| US-4808721-A | Herbicidal pyridinesulfonylureas | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0273610-A1 | Herbicidal pyridinesulfonylureas | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |
| WO-1988004297-A1 | HERBICIDAL PYRIDINESULFONYLUREAS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-06-16 | — | — | WO | disclosed |
| US-4383851-A | CONTROLLING WILD OATS IN WHEAT | THE DOW CHEMICAL COMPANY (US) | 1983-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12441705-B2 | KIF18A inhibitors | KIF18A, KIF18B, KIF15 | NAPRT 2774/4885CYP1A2 2959/4885KDM4E 1251/4885 |
| US-12441736-B2 | KIF18A inhibitors | KIF18A, KIF18B, KIF15 | NAPRT 2774/4885CYP1A2 2959/4885KDM4E 1251/4885 |
| US-20250340569-A1 | INHIBITORS OF KIF18A AND USES THEREOF | KIF18A, KIF18B, KIF2C | NAPRT 1665/4885CYP1A2 4388/4885KDM4E 3101/4885 |
| US-12540129-B2 | KIF18A inhibitors | KIF18A, KIFC1, KIF2C | NAPRT 2650/4885CYP1A2 3516/4885KDM4E 487/4885 |
| US-20250230155-A1 | 7,8-DIHYDRO-5H-1,6-NAPHTHYRIDINE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | CHRM5, CHRM4, CHRM1 | NAPRT 401/4885CYP1A2 1080/4885KDM4E 1122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.