Sugi Predict

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SCHEMBL4463018

SCHEMBL4463018

COc1ccccc1C(=O)NS(=O)(=O)c1ccc(NC(=O)C2CCC2)cc1

nearest known ligand 0.57

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 3/20 0.57
▸ KMT2A Q03164 3/20 0.57
▸ MAPT P10636 2/20 0.56
▸ HTT P42858 1/20 0.56
▸ ALDH1A1 P00352 2/20 0.54
▸ POLB P06746 1/20 0.54
▸ RXFP1 Q9HBX9 2/20 0.53
▸ RAB9A P51151 1/20 0.52
▸ THRB P10828 1/20 0.52
▸ LMNA P02545 1/20 0.51
▸ GRM4 Q14833 1/20 0.51
▸ SHMT2 P34897 1/20 0.51
▸ HPGD P15428 1/20 0.49
▸ CA1 P00915 1/20 0.49
▸ CA2 P00918 1/20 0.49
▸ CA9 Q16790 1/20 0.49
▸ SMN1; SMN2 Q16637 1/20 0.49
▸ APOBEC3G Q9HC16 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7798059 0.98 MEN1 (0.60) MEN1KMT2AMAPTHTTALDH1A1
SCHEMBL4468235 0.96 MAPT (0.61) MEN1KMT2AMAPTHTTALDH1A1
SCHEMBL4475149 0.86 LIPE (0.48) MEN1KMT2AALDH1A1RXFP1LMNA
SCHEMBL4477116 0.82 LIPE (0.50) MEN1KMT2AMAPTHTTALDH1A1
SCHEMBL15495162 0.82 RXFP1 (0.60) MEN1KMT2AMAPTHTTALDH1A1
SCHEMBL248487 0.81 RXFP1 (0.58) MEN1KMT2AALDH1A1POLBRXFP1
SCHEMBL2525599 0.81 RXFP1 (0.58) MEN1KMT2AALDH1A1POLBRXFP1
SCHEMBL22630858 0.81 RXFP1 (0.61) MEN1KMT2AMAPTALDH1A1POLB
SCHEMBL29419094 0.80 RXFP1 (0.57) MEN1KMT2AMAPTHTTALDH1A1
SCHEMBL341519 0.80 RXFP1 (0.57) MEN1KMT2AMAPTHTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8748343-B2 Herbicide/safener combintions BAYER CROPSCIENCE AG (DE) 2014-06-10 — — US disclosed
US-20120322657-A1 HERBICIDE/SAFENER COMBINTIONS ZIEMER FRANK (DE) 2012-12-20 — — US disclosed
US-7605111-B2 Herbicides SYNGENTA CROP PROTECTION, INC. (US) 2009-10-20 — — US disclosed
US-7459414-B2 Herbicides SYNGENTA CROP PROTECTION, INC. (US) 2008-12-02 — — US disclosed
US-20080200336-A1 HERBICIDAL COMPOSITION SYNEGENTA CROP PROTECTION, INC. (US) 2008-08-21 — — US disclosed
EP-1481970-B1 Novel herbicides SYNGENTA PARTICIPATIONS AG (CH) 2006-03-22 — — EP disclosed
US-20060030485-A1 Herbicide/safener combinations AVENTIS CROPSCIENCE GMBH 2006-02-09 — — US disclosed
US-6962894-B1 comprise a herbicide and a safener (counter-agent, antidote) and protect the useful plants, but not the weeds, against the phytotoxic action of the herbicide SYNGENTA CROP PROTECTION, INC. (US) 2005-11-08 — — US disclosed
US-20050187110-A1 mixtures with plant safening agents used for selectively controlling weeds and grasses in crops of useful plants MAETZKE THOMAS (CH) 2005-08-25 — — US disclosed
US-20050164883-A1 agronomically tolerable salts, isomers and enantiomers of those compounds, are suitable for use as herbicides MAETZKE THOMAS (CH) 2005-07-28 — — US disclosed
EP-1481970-A1 Novel herbicides Syngenta Participations AG (CH) 2004-12-01 — — EP disclosed
EP-1210333-B1 p-Tolyl-heterocycles as herbicides SYNGENTA PARTICIPATIONS AG (CH) 2004-11-17 — — EP disclosed
EP-1468000-A1 PHENYL SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS HERBICIDES Syngenta Participations AG (CH) 2004-10-20 — — EP disclosed
WO-2003062244-A1 PHENYL SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2003-07-31 — — WO disclosed
EP-1209975-A1 HERBICIDAL COMPOSITION Syngenta Participations AG (CH) 2002-06-05 — — EP disclosed
EP-1210333-A2 NOVEL HERBICIDES Syngenta Participations AG (CH) 2002-06-05 — — EP disclosed
EP-1130965-A1 COMBINATIONS OF HERBICIDES AND SAFENERS Aventis CropScience GmbH (DE) 2001-09-12 — — EP disclosed
WO-2001017972-A2 NOVEL HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2001-03-15 — — WO disclosed
WO-2001017353-A1 HERBICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2001-03-15 — — WO disclosed
WO-2000030447-A1 COMBINATIONS OF HERBICIDES AND SAFENERS AVENTIS CROPSCIENCE GMBH (DE) 2000-06-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120322657-A1 HERBICIDE/SAFENER COMBINTIONS DDT, DERL1, SLC16A7 MEN1 3216/4885KMT2A 528/4885MAPT 4316/4885
US-20060030485-A1 Herbicide/safener combinations DDT, DERL1, SLC16A7 MEN1 3450/4885KMT2A 605/4885MAPT 4200/4885
US-20050164883-A1 agronomically tolerable salts, isomers and enantiomers of those compounds, are suitable for use as herbicides DDT, SULT2A1, GSTA1 MEN1 2607/4885KMT2A 650/4885MAPT 2033/4885
US-20080200336-A1 HERBICIDAL COMPOSITION MTX2, DDT, AGPS MEN1 2993/4885KMT2A 2477/4885MAPT 4250/4885
US-20050187110-A1 mixtures with plant safening agents used for selectively controlling weeds and grasses in crops of useful plants PIN1, GMDS, DDT MEN1 2656/4885KMT2A 1469/4885MAPT 2885/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.